Microgravity, Stem Cells, and Cancer: A New Hope for Cancer Treatment
Humans are integrated with the environment where they live. Gravitational force plays an important role in shaping the universe, lives, and even cellular biological processes. Research in the last 40 years has shown how exposure to microgravity changes biological processes. Microgravity has been sho...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/5566872 |
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| _version_ | 1832561268512260096 |
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| author | Uğur Topal Cihan Zamur |
| author_facet | Uğur Topal Cihan Zamur |
| author_sort | Uğur Topal |
| collection | DOAJ |
| description | Humans are integrated with the environment where they live. Gravitational force plays an important role in shaping the universe, lives, and even cellular biological processes. Research in the last 40 years has shown how exposure to microgravity changes biological processes. Microgravity has been shown to have significant effects on cellular proliferation, invasion, apoptosis, migration, and gene expression, specifically in tumor cells, and these effects may also exist in stem and cancer stem cells. It has also been shown that microgravity changes the effects of chemotherapeutic drugs. Although studies have been carried out in a simulated microgravity environment in cell culture lines, there are few animal experiments or true microgravity studies. Cancer remains one of the most significant problems worldwide. Despite advances in medical science, no definitive strategies have been found for the prevention of cancer formation or to inform treatment. Thus, the microgravity environment is a potential new therapeutic strategy for future cancer treatment. This review will focus on current knowledge on the impact of the microgravity environment on cancer cells, stem cells, and the biological behavior of cancer stem cells. |
| format | Article |
| id | doaj-art-1ca62fb4f21d44949cfb9c60af703d0d |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1ca62fb4f21d44949cfb9c60af703d0d2025-02-03T01:25:26ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/55668725566872Microgravity, Stem Cells, and Cancer: A New Hope for Cancer TreatmentUğur Topal0Cihan Zamur1Department of Molecular Oncology Health Sciences Institute, Health Sciences University, Istanbul, TurkeyDepartment of Pediatrics, University of Health Sciences, Sariyer Etfal Training and Research Hospital, Istanbul, TurkeyHumans are integrated with the environment where they live. Gravitational force plays an important role in shaping the universe, lives, and even cellular biological processes. Research in the last 40 years has shown how exposure to microgravity changes biological processes. Microgravity has been shown to have significant effects on cellular proliferation, invasion, apoptosis, migration, and gene expression, specifically in tumor cells, and these effects may also exist in stem and cancer stem cells. It has also been shown that microgravity changes the effects of chemotherapeutic drugs. Although studies have been carried out in a simulated microgravity environment in cell culture lines, there are few animal experiments or true microgravity studies. Cancer remains one of the most significant problems worldwide. Despite advances in medical science, no definitive strategies have been found for the prevention of cancer formation or to inform treatment. Thus, the microgravity environment is a potential new therapeutic strategy for future cancer treatment. This review will focus on current knowledge on the impact of the microgravity environment on cancer cells, stem cells, and the biological behavior of cancer stem cells.http://dx.doi.org/10.1155/2021/5566872 |
| spellingShingle | Uğur Topal Cihan Zamur Microgravity, Stem Cells, and Cancer: A New Hope for Cancer Treatment Stem Cells International |
| title | Microgravity, Stem Cells, and Cancer: A New Hope for Cancer Treatment |
| title_full | Microgravity, Stem Cells, and Cancer: A New Hope for Cancer Treatment |
| title_fullStr | Microgravity, Stem Cells, and Cancer: A New Hope for Cancer Treatment |
| title_full_unstemmed | Microgravity, Stem Cells, and Cancer: A New Hope for Cancer Treatment |
| title_short | Microgravity, Stem Cells, and Cancer: A New Hope for Cancer Treatment |
| title_sort | microgravity stem cells and cancer a new hope for cancer treatment |
| url | http://dx.doi.org/10.1155/2021/5566872 |
| work_keys_str_mv | AT ugurtopal microgravitystemcellsandcanceranewhopeforcancertreatment AT cihanzamur microgravitystemcellsandcanceranewhopeforcancertreatment |