Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy
Juvenile idiopathic arthritis (JIA), known as Juvenile rheumatoid arthritis, is the most common type of arthritis in children aged under 17. It may cause sequelae due to lack of effective treatment. The goal of this study is to explore the therapeutic effect of umbilical cord mesenchymal stem cells...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/9165267 |
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| author | Liming Wang Yu Zhang Hongtao Li Jingxin Hong Xiaobo Chen Ming Li Wen Bai Jiangang Wang Yongjun Liu Mingyuan Wu |
| author_facet | Liming Wang Yu Zhang Hongtao Li Jingxin Hong Xiaobo Chen Ming Li Wen Bai Jiangang Wang Yongjun Liu Mingyuan Wu |
| author_sort | Liming Wang |
| collection | DOAJ |
| description | Juvenile idiopathic arthritis (JIA), known as Juvenile rheumatoid arthritis, is the most common type of arthritis in children aged under 17. It may cause sequelae due to lack of effective treatment. The goal of this study is to explore the therapeutic effect of umbilical cord mesenchymal stem cells (UC-MSCs) for JIA. Ten JIA patients were treated with UC-MSCs and received second infusion three months later. Some key values such as 28-joint disease activity score (DAS28), TNF-α, IL-6, and regulatory T cells (Tregs) were evaluated. Data were collected at 3 months and 6 months after first treatment. DAS28 score of 10 patients was between 2.6 and 3.2 at three months after infusion. WBC, ESR, and CRP were significantly decreased while Tregs were remarkably increased and IL-6 and TNF-α were declined. Similar changes of above values were found after 6 months. At the same time, the amount of NSAIDS and steroid usage in patients was reduced. However, no significant changes were found comparing the data from 3 and 6 months. These results suggest that UC-MSCs can reduce inflammatory cytokines, improve immune network effects, adjust immune tolerance, and effectively alleviate the symptoms and they might provide a safe and novel approach for JIA treatment. |
| format | Article |
| id | doaj-art-1c8f9211f16f4e6f92ddf7f34e8d9e6f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1c8f9211f16f4e6f92ddf7f34e8d9e6f2025-02-03T05:44:49ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/91652679165267Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis TherapyLiming Wang0Yu Zhang1Hongtao Li2Jingxin Hong3Xiaobo Chen4Ming Li5Wen Bai6Jiangang Wang7Yongjun Liu8Mingyuan Wu9Cell Therapy Center, 323 Hospital of People’s Liberation Army, Xi’an 710054, ChinaZhongyuan Union Cell & Gene Engineering Corporation Company, Tianjin 300304, ChinaZhongyuan Union Cell & Gene Engineering Corporation Company, Tianjin 300304, ChinaAlliancells Institute of Stem Cells and Translational Regenerative Medicine & Alliancells Bioscience Co., Ltd., Tianjin 300381, ChinaAlliancells Institute of Stem Cells and Translational Regenerative Medicine & Alliancells Bioscience Co., Ltd., Tianjin 300381, ChinaCell Therapy Center, 323 Hospital of People’s Liberation Army, Xi’an 710054, ChinaCell Therapy Center, 323 Hospital of People’s Liberation Army, Xi’an 710054, ChinaZhongyuan Union Cell & Gene Engineering Corporation Company, Tianjin 300304, ChinaZhongyuan Union Cell & Gene Engineering Corporation Company, Tianjin 300304, ChinaZhongyuan Union Cell & Gene Engineering Corporation Company, Tianjin 300304, ChinaJuvenile idiopathic arthritis (JIA), known as Juvenile rheumatoid arthritis, is the most common type of arthritis in children aged under 17. It may cause sequelae due to lack of effective treatment. The goal of this study is to explore the therapeutic effect of umbilical cord mesenchymal stem cells (UC-MSCs) for JIA. Ten JIA patients were treated with UC-MSCs and received second infusion three months later. Some key values such as 28-joint disease activity score (DAS28), TNF-α, IL-6, and regulatory T cells (Tregs) were evaluated. Data were collected at 3 months and 6 months after first treatment. DAS28 score of 10 patients was between 2.6 and 3.2 at three months after infusion. WBC, ESR, and CRP were significantly decreased while Tregs were remarkably increased and IL-6 and TNF-α were declined. Similar changes of above values were found after 6 months. At the same time, the amount of NSAIDS and steroid usage in patients was reduced. However, no significant changes were found comparing the data from 3 and 6 months. These results suggest that UC-MSCs can reduce inflammatory cytokines, improve immune network effects, adjust immune tolerance, and effectively alleviate the symptoms and they might provide a safe and novel approach for JIA treatment.http://dx.doi.org/10.1155/2016/9165267 |
| spellingShingle | Liming Wang Yu Zhang Hongtao Li Jingxin Hong Xiaobo Chen Ming Li Wen Bai Jiangang Wang Yongjun Liu Mingyuan Wu Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy Stem Cells International |
| title | Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy |
| title_full | Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy |
| title_fullStr | Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy |
| title_full_unstemmed | Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy |
| title_short | Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy |
| title_sort | clinical observation of employment of umbilical cord derived mesenchymal stem cell for juvenile idiopathic arthritis therapy |
| url | http://dx.doi.org/10.1155/2016/9165267 |
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