The total electric charge and time of application of galvanic currents to macrophages can optimize the release of IL-1β with low cell death

The total electric charge and time of application of galvanic currents to macrophages can optimize the release of IL-1β with low cell death

Abstract Galvanic current has been emerging as a novel therapy to regenerate chronic tissue lesions, including musculoskeletal and dermatological lesions. Recently, the NLRP3 inflammasome and IL-1β release have been identified as a signaling pathway triggered upon galvanic current application. Howev...

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Bibliographic Details
Main Authors: Alejandro Peñin-Franch, José Antonio García-Vidal, Ana Isabel Gómez, Pilar Escolar-Reina, Francesc Medina-Mirapeix, Pablo Pelegrín
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Percutaneous needle electrolysis
Galvanic current
Macrophage
Inflammation
IL-1β
Cell death
Online Access:https://doi.org/10.1038/s41598-024-81848-3
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https://doi.org/10.1038/s41598-024-81848-3

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