The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional study
Abstract Background The relationship between the gut microbiome and metabolic dysfunction-associated fatty liver disease (MAFLD) has garnered increasing attention. However, the association between the dietary index for gut microbiota (DI-GM), a measure of microbiome diversity, and MAFLD has yet to b...
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BMC
2025-01-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-025-01589-9 |
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| author | Yangyang Zheng Jinhui Hou Shiqi Guo Jinghai Song |
| author_facet | Yangyang Zheng Jinhui Hou Shiqi Guo Jinghai Song |
| author_sort | Yangyang Zheng |
| collection | DOAJ |
| description | Abstract Background The relationship between the gut microbiome and metabolic dysfunction-associated fatty liver disease (MAFLD) has garnered increasing attention. However, the association between the dietary index for gut microbiota (DI-GM), a measure of microbiome diversity, and MAFLD has yet to be fully explored. Methods Data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES) were analyzed, including 7243 participants. The association between DI-GM and MAFLD was investigated using weighted logistic regression, restricted cubic spline (RCS), and subgroup analyses. Results A notable inverse association was identified between DI-GM and the prevalence of MAFLD, with each 1-point increase in DI-GM corresponding to a 6.1% reduction in MAFLD prevalence (OR = 0.939, 95% CI: 0.901–0.980). Individuals with a DI-GM score of 6 or higher had an adjusted OR of 0.794 (95% CI: 0.665–0.947) compared to those with a DI-GM score of 0–3. RCS analysis further revealed a linear relationship between DI-GM and MAFLD risk. Additionally, subgroup analyses suggested that race may modify the association between DI-GM and MAFLD (P for interaction < 0.05). Conclusions DI-GM is inversely associated with MAFLD prevalence, and race appears to be a significant modifier of this relationship. |
| format | Article |
| id | doaj-art-1c87f875ce744d7c85f582ad4e37863e |
| institution | Kabale University |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-1c87f875ce744d7c85f582ad4e37863e2025-01-19T12:33:32ZengBMCDiabetology & Metabolic Syndrome1758-59962025-01-0117111110.1186/s13098-025-01589-9The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional studyYangyang Zheng0Jinhui Hou1Shiqi Guo2Jinghai Song3Department of General Surgery, Department of Hepato-bilio-pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of General Surgery, Department of Hepato-bilio-pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of General Surgery, Department of Hepato-bilio-pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of General Surgery, Department of Hepato-bilio-pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesAbstract Background The relationship between the gut microbiome and metabolic dysfunction-associated fatty liver disease (MAFLD) has garnered increasing attention. However, the association between the dietary index for gut microbiota (DI-GM), a measure of microbiome diversity, and MAFLD has yet to be fully explored. Methods Data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES) were analyzed, including 7243 participants. The association between DI-GM and MAFLD was investigated using weighted logistic regression, restricted cubic spline (RCS), and subgroup analyses. Results A notable inverse association was identified between DI-GM and the prevalence of MAFLD, with each 1-point increase in DI-GM corresponding to a 6.1% reduction in MAFLD prevalence (OR = 0.939, 95% CI: 0.901–0.980). Individuals with a DI-GM score of 6 or higher had an adjusted OR of 0.794 (95% CI: 0.665–0.947) compared to those with a DI-GM score of 0–3. RCS analysis further revealed a linear relationship between DI-GM and MAFLD risk. Additionally, subgroup analyses suggested that race may modify the association between DI-GM and MAFLD (P for interaction < 0.05). Conclusions DI-GM is inversely associated with MAFLD prevalence, and race appears to be a significant modifier of this relationship.https://doi.org/10.1186/s13098-025-01589-9Diet indexGut microbiotaDietary index for gut microbiotaMetabolic dysfunction-associated fatty liver diseaseNational Health and Nutrition Examination Survey |
| spellingShingle | Yangyang Zheng Jinhui Hou Shiqi Guo Jinghai Song The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional study Diabetology & Metabolic Syndrome Diet index Gut microbiota Dietary index for gut microbiota Metabolic dysfunction-associated fatty liver disease National Health and Nutrition Examination Survey |
| title | The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional study |
| title_full | The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional study |
| title_fullStr | The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional study |
| title_full_unstemmed | The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional study |
| title_short | The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional study |
| title_sort | association between the dietary index for gut microbiota and metabolic dysfunction associated fatty liver disease a cross sectional study |
| topic | Diet index Gut microbiota Dietary index for gut microbiota Metabolic dysfunction-associated fatty liver disease National Health and Nutrition Examination Survey |
| url | https://doi.org/10.1186/s13098-025-01589-9 |
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