PI3Kγ signaling controls trafficking of CD8+ T cells between lymphoid and non-lymphoid organs and drives hypertension in a murine model

PI3Kγ signaling controls trafficking of CD8+ T cells between lymphoid and non-lymphoid organs and drives hypertension in a murine model

Abstract Activated immune cells infiltrate the vasculature during the pathophysiology of hypertension by establishing a vascular-immune interface that contributes to blood pressure dysregulation and organ failure. Many observations indicate a key role of CD8+ T cells in hypertension but mechanisms r...

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Main Authors: Marialuisa Perrotta, Sara Perrotta, Lorenzo Carnevale, Agnese Migliaccio, Fabio Pallante, Ryszard Nosalski, Tomasz J. Guzik, Stefania Fardella, Emilio Hirsch, Valentina Fardella, Azzurra Zonfrilli, Jacopo Pacella, Matthias P. Wymann, Giuseppe Lembo, Daniela Carnevale
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61009-4
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https://doi.org/10.1038/s41467-025-61009-4

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