Upregulation of antimicrobial peptide expression in slc26a3-/- mice with colonic dysbiosis and barrier defect

Upregulation of antimicrobial peptide expression in slc26a3-/- mice with colonic dysbiosis and barrier defect

Genetic defects in SLC26A3 (DRA), an intestinal Cl−/HCO3− exchanger, result in congenital chloride diarrhea (CLD), marked by lifelong acidic diarrhea and a high risk of inflammatory bowel disease. Slc26a3−/− mice serve as a model to understand the pathophysiology of CLD and search for treatment opti...

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Main Authors: Archana Kini, Bei Zhao, Marijana Basic, Urmi Roy, Aida Iljazovic, Ivan Odak, Zhenghao Ye, Brigitte Riederer, Gabriella Di Stefano, Dorothee Römermann, Christian Koenecke, André Bleich, Till Strowig, Ursula Seidler
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
Anion exchange
intestinal electrolyte transport
inflammatory bowel disease
gut dysbiosis
antimicrobial peptides
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2041943
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https://www.tandfonline.com/doi/10.1080/19490976.2022.2041943

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