A Multifunctional Cobalt‐Containing Implant for Treating Biofilm Infections and Promoting Osteointegration in Infected Bone Defects Through Macrophage‐Mediated Immunomodulation
Abstract Treating bone infections and ensuring bone recovery is one of the major global problems facing modern orthopedics. Prolonged antibiotic use may increase the risk of antimicrobial resistance, and inflammation caused by biofilms can obstruct tissue healing, making bone infection treatment eve...
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202409200 |
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| author | Nongyang Yan Hao Zhou Penghe Jin Tengfei Li Qi Liu Hao Ning Zhixin Ma Linfei Feng Tao Jin Youwen Deng Zhengwei Wu |
| author_facet | Nongyang Yan Hao Zhou Penghe Jin Tengfei Li Qi Liu Hao Ning Zhixin Ma Linfei Feng Tao Jin Youwen Deng Zhengwei Wu |
| author_sort | Nongyang Yan |
| collection | DOAJ |
| description | Abstract Treating bone infections and ensuring bone recovery is one of the major global problems facing modern orthopedics. Prolonged antibiotic use may increase the risk of antimicrobial resistance, and inflammation caused by biofilms can obstruct tissue healing, making bone infection treatment even more challenging. The optimal treatment strategy combines immune response modification to promote osteogenesis with effective bacterial infection removal that does not require long‐term antibiotic use. A one‐step plasma immersion ion implantation approach is used to create titanium alloy implants incorporating cobalt. According to experimental findings, cobalt‐containing titanium implants exhibit improved antibacterial activity by efficiently disrupting biofilm formations and reducing Methicillin‐resistant Staphylococcus aureus adherence by over 80%. Additionally, the implants exhibit superior anti‐inflammatory and osseointegration properties. RNA sequencing analysis reveals the potential mechanism of Co2+ in regulating the polarization of macrophages toward the anti‐inflammatory M2 phenotype, which is crucial for creating an immune environment conducive to bone healing. Concurrently, these implants promote osteogenic differentiation while suppressing osteoclast activity, further supporting bone repair. Overall, without exogenous recombinant proteins or antibiotics, the implants effectively eradicate infections and expedite bone repair, offering a novel therapeutic strategy for complex skeletal diseases with clinical promise. |
| format | Article |
| id | doaj-art-1c4a9cc36e9d42f3bf60d9a67295c9fd |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-1c4a9cc36e9d42f3bf60d9a67295c9fd2025-01-20T13:04:18ZengWileyAdvanced Science2198-38442025-01-01123n/an/a10.1002/advs.202409200A Multifunctional Cobalt‐Containing Implant for Treating Biofilm Infections and Promoting Osteointegration in Infected Bone Defects Through Macrophage‐Mediated ImmunomodulationNongyang Yan0Hao Zhou1Penghe Jin2Tengfei Li3Qi Liu4Hao Ning5Zhixin Ma6Linfei Feng7Tao Jin8Youwen Deng9Zhengwei Wu10Institute of Advanced Technology University of Science and Technology of China No. 5089 Wangjiang West Road Hefei Anhui 230031 ChinaDepartment of Spine Surgery The Third Xiangya Hospital Central South University No. 138 Tongzi Road Changsha Hunan 410013 ChinaDepartment of Spine Surgery The Third Xiangya Hospital Central South University No. 138 Tongzi Road Changsha Hunan 410013 ChinaInstitute of Advanced Technology University of Science and Technology of China No. 5089 Wangjiang West Road Hefei Anhui 230031 ChinaSchool of Nuclear Science and Technology University of Science and Technology of China No. 96 Jinzhai Road Hefei Anhui 230026 ChinaDepartment of Spine Surgery The Third Xiangya Hospital Central South University No. 138 Tongzi Road Changsha Hunan 410013 ChinaComprehensive supervision office Anhui provincial Health Commission 435 Tunbrook Road Hefei 230032 ChinaSchool of Nuclear Science and Technology University of Science and Technology of China No. 96 Jinzhai Road Hefei Anhui 230026 ChinaSchool of Nuclear Science and Technology University of Science and Technology of China No. 96 Jinzhai Road Hefei Anhui 230026 ChinaDepartment of Spine Surgery The Third Xiangya Hospital Central South University No. 138 Tongzi Road Changsha Hunan 410013 ChinaInstitute of Advanced Technology University of Science and Technology of China No. 5089 Wangjiang West Road Hefei Anhui 230031 ChinaAbstract Treating bone infections and ensuring bone recovery is one of the major global problems facing modern orthopedics. Prolonged antibiotic use may increase the risk of antimicrobial resistance, and inflammation caused by biofilms can obstruct tissue healing, making bone infection treatment even more challenging. The optimal treatment strategy combines immune response modification to promote osteogenesis with effective bacterial infection removal that does not require long‐term antibiotic use. A one‐step plasma immersion ion implantation approach is used to create titanium alloy implants incorporating cobalt. According to experimental findings, cobalt‐containing titanium implants exhibit improved antibacterial activity by efficiently disrupting biofilm formations and reducing Methicillin‐resistant Staphylococcus aureus adherence by over 80%. Additionally, the implants exhibit superior anti‐inflammatory and osseointegration properties. RNA sequencing analysis reveals the potential mechanism of Co2+ in regulating the polarization of macrophages toward the anti‐inflammatory M2 phenotype, which is crucial for creating an immune environment conducive to bone healing. Concurrently, these implants promote osteogenic differentiation while suppressing osteoclast activity, further supporting bone repair. Overall, without exogenous recombinant proteins or antibiotics, the implants effectively eradicate infections and expedite bone repair, offering a novel therapeutic strategy for complex skeletal diseases with clinical promise.https://doi.org/10.1002/advs.202409200bone infection therapycobalt‐containing implantsimmunomodulationosteogenic differentiationplasma immersion ion implantation (PIII) |
| spellingShingle | Nongyang Yan Hao Zhou Penghe Jin Tengfei Li Qi Liu Hao Ning Zhixin Ma Linfei Feng Tao Jin Youwen Deng Zhengwei Wu A Multifunctional Cobalt‐Containing Implant for Treating Biofilm Infections and Promoting Osteointegration in Infected Bone Defects Through Macrophage‐Mediated Immunomodulation Advanced Science bone infection therapy cobalt‐containing implants immunomodulation osteogenic differentiation plasma immersion ion implantation (PIII) |
| title | A Multifunctional Cobalt‐Containing Implant for Treating Biofilm Infections and Promoting Osteointegration in Infected Bone Defects Through Macrophage‐Mediated Immunomodulation |
| title_full | A Multifunctional Cobalt‐Containing Implant for Treating Biofilm Infections and Promoting Osteointegration in Infected Bone Defects Through Macrophage‐Mediated Immunomodulation |
| title_fullStr | A Multifunctional Cobalt‐Containing Implant for Treating Biofilm Infections and Promoting Osteointegration in Infected Bone Defects Through Macrophage‐Mediated Immunomodulation |
| title_full_unstemmed | A Multifunctional Cobalt‐Containing Implant for Treating Biofilm Infections and Promoting Osteointegration in Infected Bone Defects Through Macrophage‐Mediated Immunomodulation |
| title_short | A Multifunctional Cobalt‐Containing Implant for Treating Biofilm Infections and Promoting Osteointegration in Infected Bone Defects Through Macrophage‐Mediated Immunomodulation |
| title_sort | multifunctional cobalt containing implant for treating biofilm infections and promoting osteointegration in infected bone defects through macrophage mediated immunomodulation |
| topic | bone infection therapy cobalt‐containing implants immunomodulation osteogenic differentiation plasma immersion ion implantation (PIII) |
| url | https://doi.org/10.1002/advs.202409200 |
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