Neprilysin 2 catalyses the degradation of natriuretic peptides despite sacubitrilat Inhibition
Abstract Neprilysin (NEP) cleaves active forms of A- and B-type natriuretic peptides (ANP and BNP) at multiple sites, reducing their compensatory effects in heart failure. Therapeutic inhibition of NEP by sacubitrilat may potentiate the beneficial effects of natriuretic peptides. Neprilysin 2 (NEP2)...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-10166-z |
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