Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation
An 83-year-old man under warfarin therapy presented for assessment of prolonged prothrombin time and cough. High-resolution computed tomography findings of the chest showed diffuse alveolar hemorrhage. His international normalized ratio (INR) was 11.89. He had been treated with rifampicin for a pers...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/4917856 |
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| _version_ | 1832556596716109824 |
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| author | Takashige Kiyota Seiji Shiota Ryosuke Hamanaka Daisuke Tsutsumi Takeshi Takakura Eishi Miyazaki |
| author_facet | Takashige Kiyota Seiji Shiota Ryosuke Hamanaka Daisuke Tsutsumi Takeshi Takakura Eishi Miyazaki |
| author_sort | Takashige Kiyota |
| collection | DOAJ |
| description | An 83-year-old man under warfarin therapy presented for assessment of prolonged prothrombin time and cough. High-resolution computed tomography findings of the chest showed diffuse alveolar hemorrhage. His international normalized ratio (INR) was 11.89. He had been treated with rifampicin for a persistent infection, but this had been discontinued about two months before admission. Rifampicin suppresses the anticoagulant activity of warfarin, which can lead to a need for increased doses of warfarin to achieve and maintain a therapeutic INR. More frequent INR monitoring is needed even after discontinuing rifampicin. |
| format | Article |
| id | doaj-art-1c265099aafa48b9b966b1b0a893c7cc |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-1c265099aafa48b9b966b1b0a893c7cc2025-02-03T05:44:53ZengWileyCase Reports in Medicine1687-96271687-96352019-01-01201910.1155/2019/49178564917856Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin DiscontinuationTakashige Kiyota0Seiji Shiota1Ryosuke Hamanaka2Daisuke Tsutsumi3Takeshi Takakura4Eishi Miyazaki5Department of General Medicine, Almeida Memorial Hospital, Oita 870-1195, JapanDepartment of General Medicine, Almeida Memorial Hospital, Oita 870-1195, JapanDepartment of General Medicine, Almeida Memorial Hospital, Oita 870-1195, JapanDepartment of General Medicine, Almeida Memorial Hospital, Oita 870-1195, JapanDepartment of General Medicine, Almeida Memorial Hospital, Oita 870-1195, JapanDepartment of General Medicine, Oita University Faculty of Medicine, Yufu 879-5593, JapanAn 83-year-old man under warfarin therapy presented for assessment of prolonged prothrombin time and cough. High-resolution computed tomography findings of the chest showed diffuse alveolar hemorrhage. His international normalized ratio (INR) was 11.89. He had been treated with rifampicin for a persistent infection, but this had been discontinued about two months before admission. Rifampicin suppresses the anticoagulant activity of warfarin, which can lead to a need for increased doses of warfarin to achieve and maintain a therapeutic INR. More frequent INR monitoring is needed even after discontinuing rifampicin.http://dx.doi.org/10.1155/2019/4917856 |
| spellingShingle | Takashige Kiyota Seiji Shiota Ryosuke Hamanaka Daisuke Tsutsumi Takeshi Takakura Eishi Miyazaki Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation Case Reports in Medicine |
| title | Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation |
| title_full | Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation |
| title_fullStr | Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation |
| title_full_unstemmed | Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation |
| title_short | Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation |
| title_sort | diffuse alveolar hemorrhage caused by warfarin after rifampicin discontinuation |
| url | http://dx.doi.org/10.1155/2019/4917856 |
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