A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.

A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.

We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of indi...

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Main Authors: George Nicholson, Mattias Rantalainen, Jia V Li, Anthony D Maher, Daniel Malmodin, Kourosh R Ahmadi, Johan H Faber, Amy Barrett, Josine L Min, N William Rayner, Henrik Toft, Maria Krestyaninova, Juris Viksna, Sudeshna Guha Neogi, Marc-Emmanuel Dumas, Ugis Sarkans, MolPAGE Consortium, Peter Donnelly, Thomas Illig, Jerzy Adamski, Karsten Suhre, Maxine Allen, Krina T Zondervan, Tim D Spector, Jeremy K Nicholson, John C Lindon, Dorrit Baunsgaard, Elaine Holmes, Mark I McCarthy, Chris C Holmes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002270&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002270&type=printable

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