Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children
Abstract Salivary cytokines have the potential to serve as biomarkers for evaluating cancer progression and treatment response in specific cancer types. This study explored salivary cytokine profiles in pediatric cancer patients and healthy controls, examining changes during chemotherapy. We conduct...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87608-1 |
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| author | Alina Paganini Nora Fritschi Cornelia Filippi Nicole Ritz Urs Simmen Katrin Scheinemann Andreas Filippi Tamara Diesch-Furlanetto |
| author_facet | Alina Paganini Nora Fritschi Cornelia Filippi Nicole Ritz Urs Simmen Katrin Scheinemann Andreas Filippi Tamara Diesch-Furlanetto |
| author_sort | Alina Paganini |
| collection | DOAJ |
| description | Abstract Salivary cytokines have the potential to serve as biomarkers for evaluating cancer progression and treatment response in specific cancer types. This study explored salivary cytokine profiles in pediatric cancer patients and healthy controls, examining changes during chemotherapy. We conducted a prospective study involving newly diagnosed cancer patients and healthy controls under 19 years old. Saliva samples were collected at diagnosis, and three and six months post-diagnosis for cancer patients, while healthy controls provided samples at a single time point. Cytokine levels were analyzed using Luminex technology. Our study included 19 cancer patients (10 with leukemia, 5 with lymphoma, and 4 with solid tumors) and 128 healthy controls aged 4 to 18 years. At diagnosis, patients with leukemia and solid tumors showed elevated levels of interferon-γ, interleukin (IL)-1α, IL-1β, IL-4, IL-5, IL-8, IL-10, and tumor necrosis factor. After three months, IL-6, IL-10, and inducible protein-10 levels significantly increased, while IL-1α, IL-1β, and IL-8 rose by six months. These findings indicate that salivary cytokines are elevated at diagnosis and during initial treatment phases in pediatric cancer patients, highlighting saliva’s potential as a noninvasive medium for early detection of systemic diseases in children. |
| format | Article |
| id | doaj-art-1bef77b96ff74ad29f7b47c281e85059 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-1bef77b96ff74ad29f7b47c281e850592025-02-02T12:24:07ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-87608-1Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy childrenAlina Paganini0Nora Fritschi1Cornelia Filippi2Nicole Ritz3Urs Simmen4Katrin Scheinemann5Andreas Filippi6Tamara Diesch-Furlanetto7Department of Oral Surgery, University Center for Dental Medicine Basel, University of BaselMycobacterial and Migrant Health Research Group, Department of Clinical Research, University of Basel Children’s Hospital, University of BaselDepartment of Children and Adolescent Dentistry, University Center for Dental Medicine Basel, University of BaselMycobacterial and Migrant Health Research Group, Department of Clinical Research, University of Basel Children’s Hospital, University of BaselSimmen Statistical ConsultingDepartment of Pediatric Oncology/Hematology, Children’s Hospital of Eastern SwitzerlandDepartment of Oral Surgery, University Center for Dental Medicine Basel, University of BaselDepartment of Pediatric Oncology/Hematology, University Children’s Hospital Basel, University of BaselAbstract Salivary cytokines have the potential to serve as biomarkers for evaluating cancer progression and treatment response in specific cancer types. This study explored salivary cytokine profiles in pediatric cancer patients and healthy controls, examining changes during chemotherapy. We conducted a prospective study involving newly diagnosed cancer patients and healthy controls under 19 years old. Saliva samples were collected at diagnosis, and three and six months post-diagnosis for cancer patients, while healthy controls provided samples at a single time point. Cytokine levels were analyzed using Luminex technology. Our study included 19 cancer patients (10 with leukemia, 5 with lymphoma, and 4 with solid tumors) and 128 healthy controls aged 4 to 18 years. At diagnosis, patients with leukemia and solid tumors showed elevated levels of interferon-γ, interleukin (IL)-1α, IL-1β, IL-4, IL-5, IL-8, IL-10, and tumor necrosis factor. After three months, IL-6, IL-10, and inducible protein-10 levels significantly increased, while IL-1α, IL-1β, and IL-8 rose by six months. These findings indicate that salivary cytokines are elevated at diagnosis and during initial treatment phases in pediatric cancer patients, highlighting saliva’s potential as a noninvasive medium for early detection of systemic diseases in children.https://doi.org/10.1038/s41598-025-87608-1SalivaChildrenOncologyLeukemia |
| spellingShingle | Alina Paganini Nora Fritschi Cornelia Filippi Nicole Ritz Urs Simmen Katrin Scheinemann Andreas Filippi Tamara Diesch-Furlanetto Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children Scientific Reports Saliva Children Oncology Leukemia |
| title | Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children |
| title_full | Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children |
| title_fullStr | Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children |
| title_full_unstemmed | Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children |
| title_short | Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children |
| title_sort | comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children |
| topic | Saliva Children Oncology Leukemia |
| url | https://doi.org/10.1038/s41598-025-87608-1 |
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