Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model
Research indicates that by 2050, more than 150 million people will be living with Alzheimer's disease (AD), a condition associated with neurodegeneration due to the accumulation of amyloid-beta and tau proteins. In addition to genetic background, endocrine disruption, and cellular senescence, m...
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| Format: | Article |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1543826/full |
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| author | Samuel de Mattos Alves Paulo Noronha Lisboa-Filho Carolina Letícia Zilli Vieira Marina Piacenti-Silva |
| author_facet | Samuel de Mattos Alves Paulo Noronha Lisboa-Filho Carolina Letícia Zilli Vieira Marina Piacenti-Silva |
| author_sort | Samuel de Mattos Alves |
| collection | DOAJ |
| description | Research indicates that by 2050, more than 150 million people will be living with Alzheimer's disease (AD), a condition associated with neurodegeneration due to the accumulation of amyloid-beta and tau proteins. In addition to genetic background, endocrine disruption, and cellular senescence, management of the gut microbiota has emerged as a key element in the diagnosis, progression, and treatment of AD, as certain bacterial metabolites can travel through the bloodstream and cross the blood-brain barrier. This mini-review explores the relationship between tau protein accumulation and gut dysbiosis in Drosophila melanogaster. This model facilitates the investigation of how gut-derived metabolites contribute to neurocognitive impairment and dementia. Understanding the role of direct and indirect bacterial by-products, such as lactate and acetate, in glial cell activation and tau protein dynamics may provide insights into the mechanisms of AD progression and contribute to more effective treatments. Here we discuss how the simplicity and extensive genetic tools of Drosophila make it a valuable model for studying these interactions and testing potential therapeutics, including probiotics. Integrating Drosophila studies with other established models may reveal conserved pathways and accelerate the translation of findings into clinical applications. |
| format | Article |
| id | doaj-art-1be3bd72ef9b47a8b400fa0fa606b018 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-1be3bd72ef9b47a8b400fa0fa606b0182025-02-04T06:32:05ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-02-011910.3389/fnins.2025.15438261543826Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a modelSamuel de Mattos Alves0Paulo Noronha Lisboa-Filho1Carolina Letícia Zilli Vieira2Marina Piacenti-Silva3Institute of Biosciences of Botucatu, Campus Botucatu, São Paulo State University (UNESP), Botucatu, SP, BrazilSchool of Sciences, Campus Bauru, São Paulo State University (UNESP), Bauru, SP, BrazilHarvard T. Chan School of Public Health, Harvard University, Boston, MA, United StatesSchool of Sciences, Campus Bauru, São Paulo State University (UNESP), Bauru, SP, BrazilResearch indicates that by 2050, more than 150 million people will be living with Alzheimer's disease (AD), a condition associated with neurodegeneration due to the accumulation of amyloid-beta and tau proteins. In addition to genetic background, endocrine disruption, and cellular senescence, management of the gut microbiota has emerged as a key element in the diagnosis, progression, and treatment of AD, as certain bacterial metabolites can travel through the bloodstream and cross the blood-brain barrier. This mini-review explores the relationship between tau protein accumulation and gut dysbiosis in Drosophila melanogaster. This model facilitates the investigation of how gut-derived metabolites contribute to neurocognitive impairment and dementia. Understanding the role of direct and indirect bacterial by-products, such as lactate and acetate, in glial cell activation and tau protein dynamics may provide insights into the mechanisms of AD progression and contribute to more effective treatments. Here we discuss how the simplicity and extensive genetic tools of Drosophila make it a valuable model for studying these interactions and testing potential therapeutics, including probiotics. Integrating Drosophila studies with other established models may reveal conserved pathways and accelerate the translation of findings into clinical applications.https://www.frontiersin.org/articles/10.3389/fnins.2025.1543826/fullAlzheimer's diseaseDrosophila melanogastergut-brain axismicrobiotaneurodegeneration |
| spellingShingle | Samuel de Mattos Alves Paulo Noronha Lisboa-Filho Carolina Letícia Zilli Vieira Marina Piacenti-Silva Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model Frontiers in Neuroscience Alzheimer's disease Drosophila melanogaster gut-brain axis microbiota neurodegeneration |
| title | Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model |
| title_full | Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model |
| title_fullStr | Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model |
| title_full_unstemmed | Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model |
| title_short | Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model |
| title_sort | alzheimer s disease and gut brain axis drosophila melanogaster as a model |
| topic | Alzheimer's disease Drosophila melanogaster gut-brain axis microbiota neurodegeneration |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1543826/full |
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