A review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in human
Background and aim: So far, no significant success has been achieved in the specific treatment of coronavirus infections. Considering that herbal medicines have beneficial effects, using herbal compounds in mild coronavirus infections can be effective. The purpose of this study is to review recent s...
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Kurdistan University of Medical Sciences
2024-11-01
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| Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
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| Online Access: | http://sjku.muk.ac.ir/article-1-7902-en.pdf |
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| author | Majid Gholami-Ahangaran Maryam Karimi-Dehkordi |
| author_facet | Majid Gholami-Ahangaran Maryam Karimi-Dehkordi |
| author_sort | Majid Gholami-Ahangaran |
| collection | DOAJ |
| description | Background and aim: So far, no significant success has been achieved in the specific treatment of coronavirus infections. Considering that herbal medicines have beneficial effects, using herbal compounds in mild coronavirus infections can be effective. The purpose of this study is to review recent studies on the effectiveness of herbal medicines in inhibiting human coronaviruses and to increase awareness for using herbal compounds as supportive medicines in reducing the severity of coronavirus infections.
Materials and methods: PubMed databases were used to search for articles containing the terms coronavirus, SARS (Severe Acute Respiratory Syndrome), and MERS (Middle East Respiratory Syndrome), as well as human and herbal medicine. The inclusion criteria were all full articles with the above-mentioned keywords and the exclusion criteria were summary articles and articles presented in conferences. A total of 35 articles on human coronaviruses were found. Most of the studies were about Covid-19 with 17 articles (48.57%). Eight articles (23.85%) were found on SARS and only one article (2.85%) on MERS. Nine articles (25.71%) on other human coronaviruses were searched and used.
Results: Some of the key compounds showing promising effects for the treatment of coronavirus in humans include scutellarein, silvestrol, tryptanthrin, psychosaponin B2, and lectins such as griffithsin, lycorine, and polyphenolics including quercetin, myristicin, caffeic acid, and isobavachalcone. The conducting clinical trials on humans, in vitro and in vivo tests are required to determine the level of safety, as well as to determine the therapeutic level for each compound.
Conclusion: Although some herbal compounds were considered for treatment in coronavirus; initial studies can focus on compounds that are already approved for medicinal use. It is hoped that using the information provided in this study, researchers will use the derivatives of natural compounds in the process of producing safe and effective anti-coronavirus therapeutic agents. |
| format | Article |
| id | doaj-art-1bcf3dc99f0a432983085d4fadc636cd |
| institution | Kabale University |
| issn | 1560-652X 2345-4040 |
| language | fas |
| publishDate | 2024-11-01 |
| publisher | Kurdistan University of Medical Sciences |
| record_format | Article |
| series | مجله علمی دانشگاه علوم پزشکی کردستان |
| spelling | doaj-art-1bcf3dc99f0a432983085d4fadc636cd2025-02-01T09:41:40ZfasKurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان1560-652X2345-40402024-11-01295125140A review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in humanMajid Gholami-Ahangaran0Maryam Karimi-Dehkordi1 Associate Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran Associate Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran Background and aim: So far, no significant success has been achieved in the specific treatment of coronavirus infections. Considering that herbal medicines have beneficial effects, using herbal compounds in mild coronavirus infections can be effective. The purpose of this study is to review recent studies on the effectiveness of herbal medicines in inhibiting human coronaviruses and to increase awareness for using herbal compounds as supportive medicines in reducing the severity of coronavirus infections. Materials and methods: PubMed databases were used to search for articles containing the terms coronavirus, SARS (Severe Acute Respiratory Syndrome), and MERS (Middle East Respiratory Syndrome), as well as human and herbal medicine. The inclusion criteria were all full articles with the above-mentioned keywords and the exclusion criteria were summary articles and articles presented in conferences. A total of 35 articles on human coronaviruses were found. Most of the studies were about Covid-19 with 17 articles (48.57%). Eight articles (23.85%) were found on SARS and only one article (2.85%) on MERS. Nine articles (25.71%) on other human coronaviruses were searched and used. Results: Some of the key compounds showing promising effects for the treatment of coronavirus in humans include scutellarein, silvestrol, tryptanthrin, psychosaponin B2, and lectins such as griffithsin, lycorine, and polyphenolics including quercetin, myristicin, caffeic acid, and isobavachalcone. The conducting clinical trials on humans, in vitro and in vivo tests are required to determine the level of safety, as well as to determine the therapeutic level for each compound. Conclusion: Although some herbal compounds were considered for treatment in coronavirus; initial studies can focus on compounds that are already approved for medicinal use. It is hoped that using the information provided in this study, researchers will use the derivatives of natural compounds in the process of producing safe and effective anti-coronavirus therapeutic agents.http://sjku.muk.ac.ir/article-1-7902-en.pdfkeywords: coronaviruscovid-19herbal medicinehumanmiddle east respiratory syndromesars-cov-2 |
| spellingShingle | Majid Gholami-Ahangaran Maryam Karimi-Dehkordi A review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in human مجله علمی دانشگاه علوم پزشکی کردستان keywords: coronavirus covid-19 herbal medicine human middle east respiratory syndrome sars-cov-2 |
| title | A review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in human |
| title_full | A review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in human |
| title_fullStr | A review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in human |
| title_full_unstemmed | A review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in human |
| title_short | A review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in human |
| title_sort | review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in human |
| topic | keywords: coronavirus covid-19 herbal medicine human middle east respiratory syndrome sars-cov-2 |
| url | http://sjku.muk.ac.ir/article-1-7902-en.pdf |
| work_keys_str_mv | AT majidgholamiahangaran areviewonphytogeniccompoundsinhibitcoronavirusesassociatedwithrespiratorysyndromeinhuman AT maryamkarimidehkordi areviewonphytogeniccompoundsinhibitcoronavirusesassociatedwithrespiratorysyndromeinhuman AT majidgholamiahangaran reviewonphytogeniccompoundsinhibitcoronavirusesassociatedwithrespiratorysyndromeinhuman AT maryamkarimidehkordi reviewonphytogeniccompoundsinhibitcoronavirusesassociatedwithrespiratorysyndromeinhuman |