Integration of amide proton transfer-weighted imaging and methionine positron emission tomography histogram parameters enhances the prediction of isocitrate dehydrogenase mutations in adult diffuse gliomas

Integration of amide proton transfer-weighted imaging and methionine positron emission tomography histogram parameters enhances the prediction of isocitrate dehydrogenase mutations in adult diffuse gliomas

Abstract Background To evaluate whether the combination of amide proton transfer-weighted imaging (APT-WI) and methionine positron emission tomography (MET-PET) enhances the non-invasive prediction of isocitrate dehydrogenase (IDH) mutation status in adult diffuse gliomas. Results We retrospectively...

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Bibliographic Details
Main Authors: Masaoki Kusunoki, Takuro Isoda, Koji Yamashita, Yoshiyuki Kitamura, Kazufumi Kikuchi, Motohiro Sando, Shingo Baba, Daisuke Kuga, Yutaka Fujioka, Fumiya Narutomi, Koji Yoshimoto, Kousei Ishigami, Osamu Togao
Format: Article
Language:English
Published: Springer 2025-04-01
Series:EJNMMI Reports
Subjects:
APT
CEST
Amino acid PET
Methionine PET
Diffuse glioma
Neuro-oncology
Online Access:https://doi.org/10.1186/s41824-025-00248-6
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