The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice
Colon cancer (CC) is the third most common tumor worldwide. Colon carcinogenesis is strongly linked to inflammation. The initiation and progression of colon cancer may be influenced by epigenetic processes. Cancer metastasis is a multistep process involving several genes and their products. During t...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/9578307 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565492809728000 |
|---|---|
| author | Jiafei Wu Decai Tang |
| author_facet | Jiafei Wu Decai Tang |
| author_sort | Jiafei Wu |
| collection | DOAJ |
| description | Colon cancer (CC) is the third most common tumor worldwide. Colon carcinogenesis is strongly linked to inflammation. The initiation and progression of colon cancer may be influenced by epigenetic processes. Cancer metastasis is a multistep process involving several genes and their products. During tumor metastasis, cancer cells first enhance their proliferative capacity by lowering autophagy and apoptosis, and then, their capacity is stimulated by boosting tumors’ ability to take nutrients from the outside via angiogenesis. Traditional treatment focuses on eliminating tumor cells by triggering cell death or activating the immune system, which often results in side effects or chemoresistance recurrence. On the contrary, Chinese medicine theory considers the patient’s entire inner system and aids in tumor shrinkage while also taking into account the mouse’ general health. Because many Chinese herbal medicines (CHM) are consumed as food, using edible CHMs as a diet resource therapy for colon cancer treatment is a viable option. Two traditional Chinese herbs, Astragalus membranaceus and Curcuma zedoaria, are commonly utilized jointly in colon cancer preventive therapy. As a result, the anticancer effect of astragalus and curcumin (AC) on colon cancer suppression in an 18-week AOM-DSS colon cancer mouse model is investigated in this research. These findings may offer a scientific foundation for investigating colon cancer diagnostic biomarkers and therapeutic application of AC in colon cancer treatment. These studies also highlighted the potential effect and mechanism of AC in the treatment of colon cancer, as well as providing insight into how to effectively use it. |
| format | Article |
| id | doaj-art-1bad5a8584ec45f9a52fcbef08a3c3b5 |
| institution | Kabale University |
| issn | 1687-630X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-1bad5a8584ec45f9a52fcbef08a3c3b52025-02-03T01:07:23ZengWileyGastroenterology Research and Practice1687-630X2022-01-01202210.1155/2022/9578307The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in MiceJiafei Wu0Decai Tang1School of Traditional Chinese Medicine and School of Integrated Chinese and Western MedicineSchool of Traditional Chinese Medicine and School of Integrated Chinese and Western MedicineColon cancer (CC) is the third most common tumor worldwide. Colon carcinogenesis is strongly linked to inflammation. The initiation and progression of colon cancer may be influenced by epigenetic processes. Cancer metastasis is a multistep process involving several genes and their products. During tumor metastasis, cancer cells first enhance their proliferative capacity by lowering autophagy and apoptosis, and then, their capacity is stimulated by boosting tumors’ ability to take nutrients from the outside via angiogenesis. Traditional treatment focuses on eliminating tumor cells by triggering cell death or activating the immune system, which often results in side effects or chemoresistance recurrence. On the contrary, Chinese medicine theory considers the patient’s entire inner system and aids in tumor shrinkage while also taking into account the mouse’ general health. Because many Chinese herbal medicines (CHM) are consumed as food, using edible CHMs as a diet resource therapy for colon cancer treatment is a viable option. Two traditional Chinese herbs, Astragalus membranaceus and Curcuma zedoaria, are commonly utilized jointly in colon cancer preventive therapy. As a result, the anticancer effect of astragalus and curcumin (AC) on colon cancer suppression in an 18-week AOM-DSS colon cancer mouse model is investigated in this research. These findings may offer a scientific foundation for investigating colon cancer diagnostic biomarkers and therapeutic application of AC in colon cancer treatment. These studies also highlighted the potential effect and mechanism of AC in the treatment of colon cancer, as well as providing insight into how to effectively use it.http://dx.doi.org/10.1155/2022/9578307 |
| spellingShingle | Jiafei Wu Decai Tang The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice Gastroenterology Research and Practice |
| title | The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice |
| title_full | The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice |
| title_fullStr | The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice |
| title_full_unstemmed | The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice |
| title_short | The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice |
| title_sort | effect and related mechanism of action of astragalus compatible with curcumin against colon cancer metastasis in mice |
| url | http://dx.doi.org/10.1155/2022/9578307 |
| work_keys_str_mv | AT jiafeiwu theeffectandrelatedmechanismofactionofastragaluscompatiblewithcurcuminagainstcoloncancermetastasisinmice AT decaitang theeffectandrelatedmechanismofactionofastragaluscompatiblewithcurcuminagainstcoloncancermetastasisinmice AT jiafeiwu effectandrelatedmechanismofactionofastragaluscompatiblewithcurcuminagainstcoloncancermetastasisinmice AT decaitang effectandrelatedmechanismofactionofastragaluscompatiblewithcurcuminagainstcoloncancermetastasisinmice |