Highly efficient and selective anticancer approach through acrolein-triggered cycloaddition chemistry in patient-derived xenografts: Mechanistic and preclinical investigation

Highly efficient and selective anticancer approach through acrolein-triggered cycloaddition chemistry in patient-derived xenografts: Mechanistic and preclinical investigation

The efficacy of anticancer treatments in the clinical setting can be improved by decreasing off-target effects. Chemistry-based methods are emerging as a promising strategy to overcome this limitation. We previously developed a prodrug strategy using mitomycin C (MMC) activated at the tumor site by...

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Bibliographic Details
Main Authors: Yuria Takahashi, Kazuki Terashima, Taiji Shimoda, Masayuki Nagahashi, Koji Morimoto, Sayaka Urano, Kozo Kataoka, Hisashi Shinohara, Yasuo Miyoshi, Ambara R. Pradipta, Katsunori Tanaka
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Tetrahedron Chem
Subjects:
[3+2] cycloaddition
Acrolein
Aryl azide
Doxorubicin
Mitomycin C
Prodrug
Online Access:http://www.sciencedirect.com/science/article/pii/S2666951X24000330
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