DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species

DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species

Abstract To elucidate the complex interplay of undifferentiated cancer cells in malignancy, we focus on the crucial mechanisms that maintain the undifferentiated state of cancer stem-like cells, which drive tumor growth and therapy resistance. Here, we identify a protein called dehydrogenase/reducta...

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Main Authors: Sunyoung Seo, Min Ji Park, Min Gi Park, Minseo Gwak, Yoonji Kim, Junseok Jang, Nayoung Hong, Bok-Sim Lee, Chohee Kim, Seonguk Jo, Hyun Bo Shim, Hyun-Jin Kim, Myung Hun Kim, Seo Hyun Yoo, Seunghyun Yoon, Sua Kim, Jae Hyuk Lee, Sang-Hun Choi, Seon Yong Lee, Gyu-Bum Yeon, Sung-Hye Park, Sung-Hak Kim, Hyunjeong Lee, Joo-Yong Lee, Dae-Sung Kim, Byung Cheon Lee, Jong-Whi Park, Hyunggee Kim
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62148-4
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https://doi.org/10.1038/s41467-025-62148-4

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