A framework for prospective, adaptive meta-analysis (FAME) of aggregate data from randomised trials.

A framework for prospective, adaptive meta-analysis (FAME) of aggregate data from randomised trials.

<h4>Background</h4>The vast majority of systematic reviews are planned retrospectively, once most eligible trials have completed and reported, and are based on aggregate data that can be extracted from publications. Prior knowledge of trial results can introduce bias into both review and...

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Main Authors: Jayne F Tierney, David J Fisher, Claire L Vale, Sarah Burdett, Larysa H Rydzewska, Ewelina Rogozińska, Peter J Godolphin, Ian R White, Mahesh K B Parmar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-05-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1003629
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