Human Genetics of Diabetic Retinopathy: Current Perspectives
Diabetic retinopathy (DR) is a most severe microvascular complication which, if left unchecked, can be sight-threatening. With the global prevalence of diabetes being relentlessly projected to rise to 438 million subjects by 2030, DR will undoubtedly pose a major public health concern. Efforts to un...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2010/172593 |
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| author | Daniel P. K. Ng |
| author_facet | Daniel P. K. Ng |
| author_sort | Daniel P. K. Ng |
| collection | DOAJ |
| description | Diabetic retinopathy (DR) is a most severe microvascular complication which, if left unchecked, can be sight-threatening. With the global prevalence of diabetes being relentlessly projected to rise to 438 million subjects by 2030, DR will undoubtedly pose a major public health concern. Efforts to unravel the human genetics of DR have been undertaken using the candidate gene and linkage approaches, while GWAS efforts are still lacking. Aside from evidence for a few genes including aldose reductase and vascular endothelial growth factor, the genetics of DR remain poorly elucidated. Nevertheless, the promise of impactful scientific discoveries may be realized if concerted and collaborative efforts are mounted to identify the genes for DR. Harnessing new genetic technologies and resources such as the upcoming 1000 Genomes Project will help advance this field of research, and potentially lead to a rich harvest of insights into the biological mechanisms underlying this debilitating complication. |
| format | Article |
| id | doaj-art-1b8d0de8739748baad68f072ea1a7b2f |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-1b8d0de8739748baad68f072ea1a7b2f2025-02-03T06:11:36ZengWileyJournal of Ophthalmology2090-004X2090-00582010-01-01201010.1155/2010/172593172593Human Genetics of Diabetic Retinopathy: Current PerspectivesDaniel P. K. Ng0Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, 16 Medical Drive MD3, 117597, SingaporeDiabetic retinopathy (DR) is a most severe microvascular complication which, if left unchecked, can be sight-threatening. With the global prevalence of diabetes being relentlessly projected to rise to 438 million subjects by 2030, DR will undoubtedly pose a major public health concern. Efforts to unravel the human genetics of DR have been undertaken using the candidate gene and linkage approaches, while GWAS efforts are still lacking. Aside from evidence for a few genes including aldose reductase and vascular endothelial growth factor, the genetics of DR remain poorly elucidated. Nevertheless, the promise of impactful scientific discoveries may be realized if concerted and collaborative efforts are mounted to identify the genes for DR. Harnessing new genetic technologies and resources such as the upcoming 1000 Genomes Project will help advance this field of research, and potentially lead to a rich harvest of insights into the biological mechanisms underlying this debilitating complication.http://dx.doi.org/10.1155/2010/172593 |
| spellingShingle | Daniel P. K. Ng Human Genetics of Diabetic Retinopathy: Current Perspectives Journal of Ophthalmology |
| title | Human Genetics of Diabetic Retinopathy: Current Perspectives |
| title_full | Human Genetics of Diabetic Retinopathy: Current Perspectives |
| title_fullStr | Human Genetics of Diabetic Retinopathy: Current Perspectives |
| title_full_unstemmed | Human Genetics of Diabetic Retinopathy: Current Perspectives |
| title_short | Human Genetics of Diabetic Retinopathy: Current Perspectives |
| title_sort | human genetics of diabetic retinopathy current perspectives |
| url | http://dx.doi.org/10.1155/2010/172593 |
| work_keys_str_mv | AT danielpkng humangeneticsofdiabeticretinopathycurrentperspectives |