Dipeptidyl peptidase-1 inhibitors in bronchiectasis

Dipeptidyl peptidase (DPP)-1 (also known as cathepsin C) inhibitors are the first disease-specific therapy shown to be effective in bronchiectasis. The mechanism of action of DPP-1 inhibitors is suppression of activity of neutrophil serine proteases (NSPs) by preventing them from being activated dur...

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Bibliographic Details
Main Authors: Emma Johnson, Amy Gilmour, James D. Chalmers
Format: Article
Language:English
Published: European Respiratory Society 2025-06-01
Series:European Respiratory Review
Online Access:http://err.ersjournals.com/content/34/176/240257.full
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