Development and mechanistic studies of calcium–BINOL phosphate-catalyzed hydrocyanation of hydrazones

Development and mechanistic studies of calcium–BINOL phosphate-catalyzed hydrocyanation of hydrazones

Asymmetric hydrocyanation of hydrazones, catalyzed by a calcium–BINOL phosphate complex, has been studied for the first time both experimentally and computationally with DFT methods. A full catalytic cycle for the enantioselective synthesis of α-hydrazinonitriles is proposed based on insights gained...

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Bibliographic Details
Main Authors: Carola Tortora, Christian A. Fischer, Sascha Kohlbauer, Alexandru Zamfir, Gerd M. Ballmann, Jürgen Pahl, Sjoerd Harder, Svetlana B. Tsogoeva
Format: Article
Language:English
Published: Beilstein-Institut 2025-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
asymmetric synthesis
calcium–binol phosphate catalysis
hydrocyanation
hydrazones
isocyanides
Online Access:https://doi.org/10.3762/bjoc.21.59
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https://doi.org/10.3762/bjoc.21.59

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