Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease
Information on the association between obesity and initial phases of chronic kidney disease (CKD) is still limited, principally those regarding the influence of visceral adipose tissue. We investigated whether the visceral adipose tissue is more associated with reductions in glomerular filtration ra...
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| Format: | Article |
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Wiley
2014-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2014/574267 |
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| author | Ana Karina Teixeira da Cunha França Alcione Miranda dos Santos João Victor Salgado Elane Viana Hortegal Antônio Augusto Moura da Silva Natalino Salgado Filho |
| author_facet | Ana Karina Teixeira da Cunha França Alcione Miranda dos Santos João Victor Salgado Elane Viana Hortegal Antônio Augusto Moura da Silva Natalino Salgado Filho |
| author_sort | Ana Karina Teixeira da Cunha França |
| collection | DOAJ |
| description | Information on the association between obesity and initial phases of chronic kidney disease (CKD) is still limited, principally those regarding the influence of visceral adipose tissue. We investigated whether the visceral adipose tissue is more associated with reductions in glomerular filtration rate (GFR) than total and abdominal obesity in hypertensive individuals with stage 1-2 CKD. A cross-sectional study was implemented which involved 241 hypertensive patients undergoing treatment at a primary health care facility. GFR was estimated using equations based on creatinine and cystatin C levels. Explanatory variables included body mass index (BMI), waist circumference (WC), and estimated visceral adipose tissue (eVAT). The mean age was 59.6±9.2 years old and 75.9% were female. According to BMI, 28.2% of subjects were obese. Prevalence of increased WC and eVAT was 63.9% and 58.5%, respectively. Results from the assessment of GFR by BMI, WC, and eVAT categories showed that only women with increased eVAT (≥150 cm2) had a lower mean GFR by Larsson (P=0.016), Levey 2 (P=0.005), and Levey 3 (P=0.008) equations. The same result was not observed when the MDRD equation was employed. No association was found between BMI, WC, eVAT, and GFR using only serum creatinine. In the early stages of CKD, increased eVAT in hypertensive women was associated with decreased GFR based on cystatin C. |
| format | Article |
| id | doaj-art-1b47e638f1154d56aaa24fc9f2bbcb25 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-1b47e638f1154d56aaa24fc9f2bbcb252025-02-03T01:02:32ZengWileyInternational Journal of Nephrology2090-214X2090-21582014-01-01201410.1155/2014/574267574267Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney DiseaseAna Karina Teixeira da Cunha França0Alcione Miranda dos Santos1João Victor Salgado2Elane Viana Hortegal3Antônio Augusto Moura da Silva4Natalino Salgado Filho5Departamento of Health Sciences, Federal University of Maranhão, São Luís, BrazilCollective Health Postgraduate Program, Federal University of Maranhão, São Luís, BrazilClinical Chemistry Service, Kidney Disease Prevention Centre, University Hospital, Federal University of Maranhão, São Luís, BrazilKidney Disease Prevention Centre, University Hospital, Federal University of Maranhão, São Luís, BrazilCollective Health Postgraduate Program, Federal University of Maranhão, São Luís, BrazilDepartment of Medicine I, Federal University of Maranhão, São Luís, BrazilInformation on the association between obesity and initial phases of chronic kidney disease (CKD) is still limited, principally those regarding the influence of visceral adipose tissue. We investigated whether the visceral adipose tissue is more associated with reductions in glomerular filtration rate (GFR) than total and abdominal obesity in hypertensive individuals with stage 1-2 CKD. A cross-sectional study was implemented which involved 241 hypertensive patients undergoing treatment at a primary health care facility. GFR was estimated using equations based on creatinine and cystatin C levels. Explanatory variables included body mass index (BMI), waist circumference (WC), and estimated visceral adipose tissue (eVAT). The mean age was 59.6±9.2 years old and 75.9% were female. According to BMI, 28.2% of subjects were obese. Prevalence of increased WC and eVAT was 63.9% and 58.5%, respectively. Results from the assessment of GFR by BMI, WC, and eVAT categories showed that only women with increased eVAT (≥150 cm2) had a lower mean GFR by Larsson (P=0.016), Levey 2 (P=0.005), and Levey 3 (P=0.008) equations. The same result was not observed when the MDRD equation was employed. No association was found between BMI, WC, eVAT, and GFR using only serum creatinine. In the early stages of CKD, increased eVAT in hypertensive women was associated with decreased GFR based on cystatin C.http://dx.doi.org/10.1155/2014/574267 |
| spellingShingle | Ana Karina Teixeira da Cunha França Alcione Miranda dos Santos João Victor Salgado Elane Viana Hortegal Antônio Augusto Moura da Silva Natalino Salgado Filho Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease International Journal of Nephrology |
| title | Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease |
| title_full | Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease |
| title_fullStr | Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease |
| title_full_unstemmed | Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease |
| title_short | Estimated Visceral Adipose Tissue, but Not Body Mass Index, Is Associated with Reductions in Glomerular Filtration Rate Based on Cystatin C in the Early Stages of Chronic Kidney Disease |
| title_sort | estimated visceral adipose tissue but not body mass index is associated with reductions in glomerular filtration rate based on cystatin c in the early stages of chronic kidney disease |
| url | http://dx.doi.org/10.1155/2014/574267 |
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