Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis
The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2–28 days after subcutaneous transplantation. The autografts stayed patent. In the al...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/510254 |
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| author | Outi E. Päiväniemi Paula K. Maasilta Tiina L. S. Vainikka Hanni S. Alho Pekka J. Karhunen Ulla-Stina Salminen |
| author_facet | Outi E. Päiväniemi Paula K. Maasilta Tiina L. S. Vainikka Hanni S. Alho Pekka J. Karhunen Ulla-Stina Salminen |
| author_sort | Outi E. Päiväniemi |
| collection | DOAJ |
| description | The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2–28 days after subcutaneous transplantation. The autografts stayed patent. In the allografts, proliferation of inflammatory cells (P<.0001) and fibroblasts (P=.02) resulted in occlusion of the bronchial lumens (P<.01). Influx of CD4+ (P<.001) and CD8+ (P<.0001) cells demonstrated allograft immune response. CRP positivity simultaneously increased in the bronchial walls (P<.01), in macrophages, myofibroblasts, and endothelial cells. Local CRP was predictive of features characteristic of OB (R=0.456–0.879, P< .05−P<.0001). Early obliterative lesions also showed CRP positivity, but not mature, collagen-rich obliterative plugs (P<.05). During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response. |
| format | Article |
| id | doaj-art-1b46b9e94f444bab8aae0cc3fd772abb |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1b46b9e94f444bab8aae0cc3fd772abb2025-02-03T05:59:30ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/510254510254Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative BronchiolitisOuti E. Päiväniemi0Paula K. Maasilta1Tiina L. S. Vainikka2Hanni S. Alho3Pekka J. Karhunen4Ulla-Stina Salminen5Department of Cardiothoracic Surgery, Helsinki University Hospital, P.O. Box 340, 00029 Helsinki, FinlandDepartment of Cardiothoracic Surgery, Helsinki University Hospital, P.O. Box 340, 00029 Helsinki, FinlandDepartment of Cardiothoracic Surgery, Helsinki University Hospital, P.O. Box 340, 00029 Helsinki, FinlandDepartment of Cardiothoracic Surgery, Helsinki University Hospital, P.O. Box 340, 00029 Helsinki, FinlandSchool of Medicine, Tampere University, 33104 Tampere, FinlandDepartment of Cardiothoracic Surgery, Helsinki University Hospital, P.O. Box 340, 00029 Helsinki, FinlandThe local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2–28 days after subcutaneous transplantation. The autografts stayed patent. In the allografts, proliferation of inflammatory cells (P<.0001) and fibroblasts (P=.02) resulted in occlusion of the bronchial lumens (P<.01). Influx of CD4+ (P<.001) and CD8+ (P<.0001) cells demonstrated allograft immune response. CRP positivity simultaneously increased in the bronchial walls (P<.01), in macrophages, myofibroblasts, and endothelial cells. Local CRP was predictive of features characteristic of OB (R=0.456–0.879, P< .05−P<.0001). Early obliterative lesions also showed CRP positivity, but not mature, collagen-rich obliterative plugs (P<.05). During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response.http://dx.doi.org/10.1155/2009/510254 |
| spellingShingle | Outi E. Päiväniemi Paula K. Maasilta Tiina L. S. Vainikka Hanni S. Alho Pekka J. Karhunen Ulla-Stina Salminen Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis Mediators of Inflammation |
| title | Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis |
| title_full | Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis |
| title_fullStr | Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis |
| title_full_unstemmed | Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis |
| title_short | Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis |
| title_sort | local c reactive protein expression in obliterative lesions and the bronchial wall in posttransplant obliterative bronchiolitis |
| url | http://dx.doi.org/10.1155/2009/510254 |
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