An Optimised Live Attenuated Influenza Vaccine Ferret Efficacy Model Successfully Translates H1N1 Clinical Data

An Optimised Live Attenuated Influenza Vaccine Ferret Efficacy Model Successfully Translates H1N1 Clinical Data

Between 2013 and 2016, the A/H1N1pdm09 component of the live attenuated influenza vaccine (LAIV) produced instances of lower-than-expected vaccine effectiveness. Standard pre-clinical ferret models, using a human-like vaccine dose and focusing on antigenic match to circulating wildtype (<i>wt&...

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Bibliographic Details
Main Authors: Katarzyna E. Schewe, Shaun Cooper, Jonathan Crowe, Steffan Llewellyn, Lydia Ritter, Kathryn A. Ryan, Oliver Dibben
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Vaccines
Subjects:
influenza virus
live attenuated influenza vaccine
ferret
animal model
clinical translatability
vaccine efficacy
Online Access:https://www.mdpi.com/2076-393X/12/11/1275
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