rSNP_Guide-BASED EVALUATION OF SNPs IN PROMOTеRS OF THE HUMAN APC AND MLH1 GENES ASSOCIATED WITH COLON CANCER

rSNP_Guide-BASED EVALUATION OF SNPs IN PROMOTеRS OF THE HUMAN APC AND MLH1 GENES ASSOCIATED WITH COLON CANCER

Six regulatory SNPs (single nucleotide polymorphisms) of two human APC and MLH1 genes (rs75996864, rs76241113, rs78037487, rs80112297, rs80313086 and rs1800734) were evaluated by the previously developed rSNP_Guide method to compute the significance of the changes for binding of the SNP region with...

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Bibliographic Details
Main Authors: D. A. Rasskazov, E. V. Antontseva, L. O. Bryzgalov, M. Yu. Matveeva, E. V. Kashina, P. M. Ponomarenko, G. V. Orlova, M. P. Ponomarenko, D. A. Afonnikov, T. I. Merkulova
Format: Article
Language:English
Published: Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2015-01-01
Series:Вавиловский журнал генетики и селекции
Subjects:
single-nucleotide polymorphism
gene expression regulation
colon cancer
apc
mlh1 genes
dna–regulatory protein complex
student’s t-test
Online Access:https://vavilov.elpub.ru/jour/article/view/182
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