Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications
High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to in...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/7806435 |
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| author | Bou-Yue Peng Navneet Kumar Dubey Viraj Krishna Mishra Feng-Chou Tsai Rajni Dubey Win-Ping Deng Hong-Jian Wei |
| author_facet | Bou-Yue Peng Navneet Kumar Dubey Viraj Krishna Mishra Feng-Chou Tsai Rajni Dubey Win-Ping Deng Hong-Jian Wei |
| author_sort | Bou-Yue Peng |
| collection | DOAJ |
| description | High morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications. These complications affect the normal function of organ and tissues and may cause life-threatening disorders, if hyperglycemia persists and improperly controlled. Current and traditional treatment procedures are only focused on to regulate the insulin level and do not cure the diabetic complications. Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. Previous studies have demonstrated the various impacts of both pluripotent and multipotent stem cells on DM and its micro- and macrovascular complications. Therefore, this review summarizes the potential of stem cells to treat DM and its related complications. |
| format | Article |
| id | doaj-art-1afe6221543e4c98b4d41f0a608ce5c2 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1afe6221543e4c98b4d41f0a608ce5c22025-02-03T05:59:19ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/78064357806435Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its ComplicationsBou-Yue Peng0Navneet Kumar Dubey1Viraj Krishna Mishra2Feng-Chou Tsai3Rajni Dubey4Win-Ping Deng5Hong-Jian Wei6School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei City 110, TaiwanCeramics and Biomaterials Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, VietnamApplied Biotech Engineering Centre (ABEC), Department of Biotechnology, Ambala College of Engineering and Applied Research, Ambala, IndiaDepartment of Stem Cell Research, Cosmetic Clinic Group, Taipei City 110, TaiwanGraduate Institute of Food Science and Technology, National Taiwan University, Taipei City 106, TaiwanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei City 110, TaiwanStem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei, TaiwanHigh morbidity and mortality of diabetes mellitus (DM) throughout the human population is a serious threat which needs to be addressed cautiously. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are most prevalent forms. Disruption in insulin regulation and resistance leads to increased formation and accumulation of advanced end products (AGEs), which further enhance oxidative and nitrosative stress leading to microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular complications. These complications affect the normal function of organ and tissues and may cause life-threatening disorders, if hyperglycemia persists and improperly controlled. Current and traditional treatment procedures are only focused on to regulate the insulin level and do not cure the diabetic complications. Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. Previous studies have demonstrated the various impacts of both pluripotent and multipotent stem cells on DM and its micro- and macrovascular complications. Therefore, this review summarizes the potential of stem cells to treat DM and its related complications.http://dx.doi.org/10.1155/2018/7806435 |
| spellingShingle | Bou-Yue Peng Navneet Kumar Dubey Viraj Krishna Mishra Feng-Chou Tsai Rajni Dubey Win-Ping Deng Hong-Jian Wei Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications Journal of Diabetes Research |
| title | Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications |
| title_full | Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications |
| title_fullStr | Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications |
| title_full_unstemmed | Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications |
| title_short | Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications |
| title_sort | addressing stem cell therapeutic approaches in pathobiology of diabetes and its complications |
| url | http://dx.doi.org/10.1155/2018/7806435 |
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