Trace elements in children with pre-dialysis and end-stage renal disease
Background/Aim: Chronic kidney disease (CKD) impacts 11-13 % of world wild population and can lead to end-stage renal disease (ESRD). Paediatric CKD is connected with considerable morbidity and necessity for early management. Trace elements as iron (Fe), zinc (Zn) and copper (Cu) are required for a...
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2024-01-01
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| Series: | Scripta Medica |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2024/2490-33292406697A.pdf |
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| author | Alsalam Asmaa Abd Ali Ruaa H. Hussain Haider K. Mahdi Montadher Ali |
| author_facet | Alsalam Asmaa Abd Ali Ruaa H. Hussain Haider K. Mahdi Montadher Ali |
| author_sort | Alsalam Asmaa Abd |
| collection | DOAJ |
| description | Background/Aim: Chronic kidney disease (CKD) impacts 11-13 % of world wild population and can lead to end-stage renal disease (ESRD). Paediatric CKD is connected with considerable morbidity and necessity for early management. Trace elements as iron (Fe), zinc (Zn) and copper (Cu) are required for a variety of physiological activities and may influence CKD progression. The main goal of this work was to analyse the amounts of trace elements among children with CKD and ESRD and their potential as disease stage biomarkers. Methods: The study comprised 40 pre-dialysis CKD patients, 40 dialysis-dependent ESRD patients and 40 healthy controls aged 0 to 19 years. Blood samples were obtained and tested for Fe, Zn and Cu levels utilising flame-atomic absorption spectrophotometry (FAAS). Anthropometric data, such as age, body mass index (BMI) and blood pressure, were also collected. The statistical calculations were done by the utilising of SPSS version 25.0. Results: Trace element levels varied significantly between groups. Cu levels were higher, while Fe and Zn concentrations were lower in CKD and patients on dialysis compared to controls, with Zn exhibiting the greatest drop. Zn had the highest accuracy as a biomarker for CKD and ESRD, with an the area under the curve (AUC) of 0.999, sensitivity of 100 % and specificity of 98 %. Conclusion: Zn is a promising biomarker for detecting CKD development and distinguishing between CKD stages and ESRD. Regular trace element monitoring is critical for controlling paediatric chronic kidney disease and improving patients' consequences. Further research is needed to determine the therapeutic potential of trace element management in CKD. |
| format | Article |
| id | doaj-art-1afd1e6bb36642a686e6041480e8f560 |
| institution | Kabale University |
| issn | 2490-3329 2303-7954 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj-art-1afd1e6bb36642a686e6041480e8f5602025-02-05T13:19:48ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542024-01-0155669770610.5937/scriptamed55-539332490-33292406697ATrace elements in children with pre-dialysis and end-stage renal diseaseAlsalam Asmaa Abd0https://orcid.org/0009-0005-9154-7232Ali Ruaa H.1https://orcid.org/0009-0003-1501-9871Hussain Haider K.2https://orcid.org/0000-0002-3054-0572Mahdi Montadher Ali3https://orcid.org/0000-0002-6896-9278University of Fallujah, College of Education, Department of Biology, Baghdad, IraqAl-Nahrain University, Higher Institute of Forensic Science, Jadriya, Baghdad, IraqAl-Nahrain University, Forensic DNA Centre for Research and Training, Department of Molecular Genetics and DNA Fingerprint, Jadriya, Baghdad, IraqUniversity of Baghdad, National Centre for Cancer Research, Baghdad, IraqBackground/Aim: Chronic kidney disease (CKD) impacts 11-13 % of world wild population and can lead to end-stage renal disease (ESRD). Paediatric CKD is connected with considerable morbidity and necessity for early management. Trace elements as iron (Fe), zinc (Zn) and copper (Cu) are required for a variety of physiological activities and may influence CKD progression. The main goal of this work was to analyse the amounts of trace elements among children with CKD and ESRD and their potential as disease stage biomarkers. Methods: The study comprised 40 pre-dialysis CKD patients, 40 dialysis-dependent ESRD patients and 40 healthy controls aged 0 to 19 years. Blood samples were obtained and tested for Fe, Zn and Cu levels utilising flame-atomic absorption spectrophotometry (FAAS). Anthropometric data, such as age, body mass index (BMI) and blood pressure, were also collected. The statistical calculations were done by the utilising of SPSS version 25.0. Results: Trace element levels varied significantly between groups. Cu levels were higher, while Fe and Zn concentrations were lower in CKD and patients on dialysis compared to controls, with Zn exhibiting the greatest drop. Zn had the highest accuracy as a biomarker for CKD and ESRD, with an the area under the curve (AUC) of 0.999, sensitivity of 100 % and specificity of 98 %. Conclusion: Zn is a promising biomarker for detecting CKD development and distinguishing between CKD stages and ESRD. Regular trace element monitoring is critical for controlling paediatric chronic kidney disease and improving patients' consequences. Further research is needed to determine the therapeutic potential of trace element management in CKD.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2024/2490-33292406697A.pdfrenal insufficiency, chronicchildrenrenal dialysistrace elementszinc |
| spellingShingle | Alsalam Asmaa Abd Ali Ruaa H. Hussain Haider K. Mahdi Montadher Ali Trace elements in children with pre-dialysis and end-stage renal disease Scripta Medica renal insufficiency, chronic children renal dialysis trace elements zinc |
| title | Trace elements in children with pre-dialysis and end-stage renal disease |
| title_full | Trace elements in children with pre-dialysis and end-stage renal disease |
| title_fullStr | Trace elements in children with pre-dialysis and end-stage renal disease |
| title_full_unstemmed | Trace elements in children with pre-dialysis and end-stage renal disease |
| title_short | Trace elements in children with pre-dialysis and end-stage renal disease |
| title_sort | trace elements in children with pre dialysis and end stage renal disease |
| topic | renal insufficiency, chronic children renal dialysis trace elements zinc |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2024/2490-33292406697A.pdf |
| work_keys_str_mv | AT alsalamasmaaabd traceelementsinchildrenwithpredialysisandendstagerenaldisease AT aliruaah traceelementsinchildrenwithpredialysisandendstagerenaldisease AT hussainhaiderk traceelementsinchildrenwithpredialysisandendstagerenaldisease AT mahdimontadherali traceelementsinchildrenwithpredialysisandendstagerenaldisease |