Antimicrobial Resistance of Enteric Salmonella in Bangui, Central African Republic
Introduction. The number of Salmonella isolated from clinical samples that are resistant to multiple antibiotics has increased worldwide. The aim of this study was to determine the prevalence of resistant Salmonella enterica isolated in Bangui. Methods. All enteric Salmonella strains isolated from p...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/483974 |
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| author | Christian Diamant Mossoro-Kpinde Alexandre Manirakiza Jean-Robert Mbecko Pembé Misatou Alain Le Faou Thierry Frank |
| author_facet | Christian Diamant Mossoro-Kpinde Alexandre Manirakiza Jean-Robert Mbecko Pembé Misatou Alain Le Faou Thierry Frank |
| author_sort | Christian Diamant Mossoro-Kpinde |
| collection | DOAJ |
| description | Introduction. The number of Salmonella isolated from clinical samples that are resistant to multiple antibiotics has increased worldwide. The aim of this study was to determine the prevalence of resistant Salmonella enterica isolated in Bangui. Methods. All enteric Salmonella strains isolated from patients in 2008 were identified and serotyped, and the phenotypes of resistance were determined by using the disk diffusion method. Nine resistance-associated genes, blaTEM, blaOXA, blaSHV, tetA, aadA1, catA1, dhfrA1, sul I, and sul II, were sought by genic amplification in seven S.e. Typhimurium strains. Results. The 94 strains isolated consisted of 47 S.e. Typhimurium (50%), 21 S.e. Stanleyville (22%), 18 S.e. Enteritidis (19%), 4 S.e. Dublin (4%), 4 S.e. Hadar (4%), and 1 S.e. Papuana (1%). Twenty-five (28%) were multiresistant, including 20 of the Typhimurium serovar (80%). Two main phenotypes of resistance were found: four antibiotics (56%) and to five antibiotics (40%). One S.e. Typhimurium isolate produced an extended-spectrum β-lactamase (ESBL). Only seven strains of S.e. Typhimurium could be amplified genically. Only phenotypic resistance to tetracycline and aminosides was found. Conclusion. S. Typhimurium is the predominant serovar of enteric S. enterica and is the most widely resistant. The search for resistance genes showed heterogeneity of the circulating strains. |
| format | Article |
| id | doaj-art-1ac17fb3b2e84e82800b4b35fd94ffc7 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-1ac17fb3b2e84e82800b4b35fd94ffc72025-02-03T06:13:13ZengWileyJournal of Tropical Medicine1687-96861687-96942015-01-01201510.1155/2015/483974483974Antimicrobial Resistance of Enteric Salmonella in Bangui, Central African RepublicChristian Diamant Mossoro-Kpinde0Alexandre Manirakiza1Jean-Robert Mbecko2Pembé Misatou3Alain Le Faou4Thierry Frank5Laboratoire de l’Hôpital Maman Elisabeth Domitien, Bimbo, Central African RepublicInstitut Pasteur de Bangui, P.O. Box 923, Bangui, Central African RepublicInstitut Pasteur de Bangui, P.O. Box 923, Bangui, Central African RepublicInstitut Pasteur de Bangui, P.O. Box 923, Bangui, Central African RepublicFaculté de Médecine and EA 3452, Cithefor, Faculté de Pharmacie, Université de Lorraine, Nancy, FranceInstitut Pasteur de Bangui, P.O. Box 923, Bangui, Central African RepublicIntroduction. The number of Salmonella isolated from clinical samples that are resistant to multiple antibiotics has increased worldwide. The aim of this study was to determine the prevalence of resistant Salmonella enterica isolated in Bangui. Methods. All enteric Salmonella strains isolated from patients in 2008 were identified and serotyped, and the phenotypes of resistance were determined by using the disk diffusion method. Nine resistance-associated genes, blaTEM, blaOXA, blaSHV, tetA, aadA1, catA1, dhfrA1, sul I, and sul II, were sought by genic amplification in seven S.e. Typhimurium strains. Results. The 94 strains isolated consisted of 47 S.e. Typhimurium (50%), 21 S.e. Stanleyville (22%), 18 S.e. Enteritidis (19%), 4 S.e. Dublin (4%), 4 S.e. Hadar (4%), and 1 S.e. Papuana (1%). Twenty-five (28%) were multiresistant, including 20 of the Typhimurium serovar (80%). Two main phenotypes of resistance were found: four antibiotics (56%) and to five antibiotics (40%). One S.e. Typhimurium isolate produced an extended-spectrum β-lactamase (ESBL). Only seven strains of S.e. Typhimurium could be amplified genically. Only phenotypic resistance to tetracycline and aminosides was found. Conclusion. S. Typhimurium is the predominant serovar of enteric S. enterica and is the most widely resistant. The search for resistance genes showed heterogeneity of the circulating strains.http://dx.doi.org/10.1155/2015/483974 |
| spellingShingle | Christian Diamant Mossoro-Kpinde Alexandre Manirakiza Jean-Robert Mbecko Pembé Misatou Alain Le Faou Thierry Frank Antimicrobial Resistance of Enteric Salmonella in Bangui, Central African Republic Journal of Tropical Medicine |
| title | Antimicrobial Resistance of Enteric Salmonella in Bangui, Central African Republic |
| title_full | Antimicrobial Resistance of Enteric Salmonella in Bangui, Central African Republic |
| title_fullStr | Antimicrobial Resistance of Enteric Salmonella in Bangui, Central African Republic |
| title_full_unstemmed | Antimicrobial Resistance of Enteric Salmonella in Bangui, Central African Republic |
| title_short | Antimicrobial Resistance of Enteric Salmonella in Bangui, Central African Republic |
| title_sort | antimicrobial resistance of enteric salmonella in bangui central african republic |
| url | http://dx.doi.org/10.1155/2015/483974 |
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