Survival benefit from abemaciclib in non–small cell lung cancer by Kirsten rat sarcoma–mutation gene expression subtype: retrospective analysis from the JUNIPER Trial

Survival benefit from abemaciclib in non–small cell lung cancer by Kirsten rat sarcoma–mutation gene expression subtype: retrospective analysis from the JUNIPER Trial

PurposeJUNIPER, a randomized, phase III trial of patients with stage IV non–small cell lung cancer and a detectable Kristen rat sarcoma (KRAS) mutation in codons 12 or 13 whose condition progressed after platinum-based chemotherapy and up to 1 additional therapy (could include immune checkpoint inhi...

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Main Authors: Jiangang Liu, Hong Wang, Amit Aggarwal, Maria Jesus Ortiz-Ruiz, Elisabet Zapatero-Solana, Maria Jose Lallena, Sandra Peregrina, Gloria Martinez del Hoyo, Susana Velasco, Philip J. Ebert, Xueqian Gong, Anwar M. Hossain, Shawn T. Estrem
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
Subjects:
biomarkers
CDK4
CDK6
KRAS
non-small cell lung cancer clinical trial registration: NCT02152631
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1461530/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1461530/full

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