Characteristics of TPT initiation and completion among people living with HIV

Characteristics of TPT initiation and completion among people living with HIV

BACKGROUND: TB preventive treatment (TPT) reduces morbidity and mortality among people living with HIV (PLHIV). Despite the successful scale-up of TPT in Malawi, monitoring and evaluation have been suboptimal. We utilized the Malawi Population-Based HIV Impact Assessment (MPHIA) 2020–2021 survey dat...

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Main Authors: L. Gunde, A. Wang, D. Payne, S. O'Connor, A. Kabaghe, N. Kalata, A. Maida, D. Kayira, V. Buie, L. Tauzi, A. Sankhani, A. Thawani, E. Rambiki, A. Ahimbisibwe, T. Maphosa, K. Kudiabor, R. Nyirenda, J. Mpunga, K. Mbendera, P. Nyasulu, F. Kayigamba, M. Farahani, A. C. Voetsch, K. Brown, A. Jahn, B. Girma, K. Mirkovic, the MPHIA Survey Team
Format: Article
Language:English
Published: International Union Against Tuberculosis and Lung Disease (The Union) 2024-01-01
Series:IJTLD Open
Subjects:
tuberculosis
epidemiology
prevention
Online Access:https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000001/art00004
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Summary:BACKGROUND: TB preventive treatment (TPT) reduces morbidity and mortality among people living with HIV (PLHIV). Despite the successful scale-up of TPT in Malawi, monitoring and evaluation have been suboptimal. We utilized the Malawi Population-Based HIV Impact Assessment (MPHIA) 2020–2021 survey data to estimate TPT uptake and completion among self-reported HIV-positive persons. METHODS: We estimated the proportion of HIV-positive respondents who had ever undergone TPT, and determined the percentage of those currently on TPT who had completed more than 6 months of treatment. Bivariate and multivariable logistic regression were performed to calculate the odds ratios for factors associated with ever-taking TPT. All variables were self-reported, and the analysis was weighted and accounted for in the survey design. RESULTS: Of the HIV+ respondents, 38.8% (95% CI 36.4–41.3) had ever taken TPT. The adjusted odds of ever taking TPT were 8.0 and 5.2 times as high in the Central and Southern regions, respectively, compared to the Northern region; 1.9 times higher among those in the highest wealth quintile, and 2.1 times higher for those on antiretroviral therapy >10 years. Of those currently taking TPT, 56.2% completed >6 months of TPT. CONCLUSIONS: These results suggest low TPT uptake and >6 months’ completion rates among self-reported HIV+ persons. Initiatives to create demand and strengthen adherence would improve TPT uptake.
ISSN:3005-7590

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