Nicotinamide Mononucleotide (NMN) Improves the Senescence of Mouse Vascular Smooth Muscle Cells Induced by Ang II Through Activating p-AMPK/KLF4 Pathway

Nicotinamide Mononucleotide (NMN) Improves the Senescence of Mouse Vascular Smooth Muscle Cells Induced by Ang II Through Activating p-AMPK/KLF4 Pathway

<b>Background</b>: Vascular smooth muscle cells (VSMCs) senescence exacerbates vascular diseases like atherosclerosis and hypertension. Angiotensin II (Ang II) is a strong inducer of VSMCs senescence, causing vascular damage, though its exact mechanism is unclear. Nicotinamide mononucleo...

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Bibliographic Details
Main Authors: Na Liang, Si Liu, Yan Wang, Linyao Ying, Keyi Zhang, Hao Li, Lin Xiao, Yuming Hu, Gang Luo
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceuticals
Subjects:
nicotinamide mononucleotide
vascular smooth muscle cells
senescence
AMPK/KLF4/p16 pathway
Angiotensin II
Online Access:https://www.mdpi.com/1424-8247/18/4/553
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