Two distinct subpopulations of human stem-like memory T cells exhibit complementary roles in self-renewal and clonal longevity.

Two distinct subpopulations of human stem-like memory T cells exhibit complementary roles in self-renewal and clonal longevity.

T stem cell-like memory cells (TSCM cells) are considered to be essential for the maintenance of immune memory. The TSCM population has been shown to have the key properties of a stem cell population: multipotency, self-renewal and clonal longevity. Here we show that no single population has all the...

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Main Authors: Danai Koftori, Charandeep Kaur, Laura Mora Bitria, Yan Zhang, Linda Hadcocks, Ada W C Yan, Piotr F Burzyński, Kristin Ladell, Daniel E Speiser, Katrina M Pollock, Derek Macallan, Becca Asquith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003179
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https://doi.org/10.1371/journal.pbio.3003179

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