Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation

Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation

IntroductionDuring acute inflammation, immune-to-brain signaling plays a pivotal role in the generation of sickness responses such as fever or hypothermia. Neutrophil granulocytes (NG) are a crucial component of the immune system and modulate inflammation. Moreover, neutropenic fever is a severe con...

Full description

Saved in:
Bibliographic Details
Main Authors: Jessica Hernandez, Fabian Johannes Pflieger, Julia Schäffer, Leona Bähr, Jenny Schneiders, Thomas Reichel, Marita Meurer, Benjamin Lamp, Natali Bettina Bauer, Karsten Krüger, Lois Harden, Maren von Köckritz-Blickwede, Christoph Rummel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
neutrophil granulocytes
neutropenia
inflammation
hypothermia
sickness response
immune-to-brain signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578590/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578590/full

Similar Items