Generation, interrogation, and future applications of microglia-containing brain organoids

Generation, interrogation, and future applications of microglia-containing brain organoids

Brain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and function. First, this review provides a brief introduction to the current state-of-the-art for neuro-ectoderm brain organoid develo...

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Bibliographic Details
Main Authors: Julia Di Stefano, Federica Di Marco, Ilaria Cicalini, Una FitzGerald, Damiana Pieragostino, Marleen Verhoye, Peter Ponsaerts, Elise Van Breedam
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-12-01
Series:Neural Regeneration Research
Subjects:
3d cell culture
brain organoids
immune response
immunocompetent model
in vitro model
microglia
neural organoids
neuroimmunology
neuroinflammation
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-00921
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