Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis
ABSTRACT Background Duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used to treat various health conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, and off‐label for chemotherapy‐induced pain. We conducted this systematic review and...
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Wiley
2025-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70217 |
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| author | Abdulsalam Mohammed Aleid Faisal Alshehri Naif Alasiri Fatimah Alhomoud Shouq Alsaegh Mohammed Alrasheed Salem Aljaddua Ali Alasiri Asma Boukhari Abdulmonem Ali Alhussain Bipin Chaurasia Saud Nayef Aldanyowi |
| author_facet | Abdulsalam Mohammed Aleid Faisal Alshehri Naif Alasiri Fatimah Alhomoud Shouq Alsaegh Mohammed Alrasheed Salem Aljaddua Ali Alasiri Asma Boukhari Abdulmonem Ali Alhussain Bipin Chaurasia Saud Nayef Aldanyowi |
| author_sort | Abdulsalam Mohammed Aleid |
| collection | DOAJ |
| description | ABSTRACT Background Duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used to treat various health conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, and off‐label for chemotherapy‐induced pain. We conducted this systematic review and meta‐analysis aiming to test the current evidence regarding effectiveness and safety of duloxetine for postspine surgeries pain. Methods We searched the Cochrane Central Register of Controlled Trials, PubMed, Scopus and Web of science databases for relevant articles up to March 2024. The following search terms were Used in combination using the Boolean operators ((Duloxetine Hydrochloride) AND ((Pain, Postoperative) OR (Postoperative Period) OR (Postoperative Cognitive Complications) OR (Delayed Emergence from Anesthesia) OR (Postoperative Care) OR (spine surgery)) without time constrain for the search. Meta‐analysis was performed using Review Manager (RevMan version 5.4) on the extracted outcome data that present in at least 3 of the included studies. Mean difference (MD) was used as the effect size for continuous outcomes with a 95% confidence interval (CI) or standardized mean difference (SMD) in case of different outcome reporting scales. Results Pooled analysis showed that duloxetine significantly reduces pain intensity after 24 h from the operation compared to placebo (SMD = −1.11, 95% CI [−2.16 to −0.07], p = 0.04) with no significant difference in pain after 2 and 48 h. Meta‐analysis revealed that duloxetine shows a significant reduction in the amount of analgesic consumption after 24 h postoperative; (MD = −3.33, 95% CI [−5.53 to −1.13], p = 0.003). The analysis did not show any statistically significant difference between duloxetine and placebo in patients experiencing nausea or vomiting (RR = 1.37, 95% CI [0.62 to 3.00] Conclusion The findings of this study suggest that duloxetine may be effective in reducing pain 24 h after spine surgery. Furthermore, there is a promising effect of duloxetine in treating chronic postoperative pain. However, it is important to acknowledge that further research is warranted to thoroughly evaluate the efficacy and safety of duloxetine for relieving chronic postoperative pain. |
| format | Article |
| id | doaj-art-19d14bf2048a4fafa245cbc7ae8b943d |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-19d14bf2048a4fafa245cbc7ae8b943d2025-01-29T13:36:39ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70217Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐AnalysisAbdulsalam Mohammed Aleid0Faisal Alshehri1Naif Alasiri2Fatimah Alhomoud3Shouq Alsaegh4Mohammed Alrasheed5Salem Aljaddua6Ali Alasiri7Asma Boukhari8Abdulmonem Ali Alhussain9Bipin Chaurasia10Saud Nayef Aldanyowi11Department of Surgery, Medical CollegeKing Faisal UniversityHofuf, AhsaSaudi ArabiaDepartment of surgeryKing Khalid UniversityAbha Saudi ArabiaDepartment of surgeryKing Khalid UniversityAbha Saudi ArabiaDepartment of surgeryImam Abdulrahman Bin Faisal UniversityDammam Saudi ArabiaDepartment of surgeryQassim UniversityUnaizah Saudi ArabiaDepartment of surgeryKing Saud Bin Abdulaziz University for Health SciencesRiyadh Saudi ArabiaDepartment of surgeryJouf UniversityAljouf Saudi ArabiaDepartment of surgeryRijal Almaa General HospitalRijal Almaa Saudi ArabiaDepartment of surgeryKing Khalid UniversityAbha Saudi ArabiaDepartment of NeurosurgeryKing Fahad HospitalHofuf, AhsaSaudi ArabiaDepartment of NeurosurgeryNeurosurgery ClinicBirgunjNepalDepartment of Surgery, Medical CollegeKing Faisal UniversityHofuf, AhsaSaudi ArabiaABSTRACT Background Duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used to treat various health conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, and off‐label for chemotherapy‐induced pain. We conducted this systematic review and meta‐analysis aiming to test the current evidence regarding effectiveness and safety of duloxetine for postspine surgeries pain. Methods We searched the Cochrane Central Register of Controlled Trials, PubMed, Scopus and Web of science databases for relevant articles up to March 2024. The following search terms were Used in combination using the Boolean operators ((Duloxetine Hydrochloride) AND ((Pain, Postoperative) OR (Postoperative Period) OR (Postoperative Cognitive Complications) OR (Delayed Emergence from Anesthesia) OR (Postoperative Care) OR (spine surgery)) without time constrain for the search. Meta‐analysis was performed using Review Manager (RevMan version 5.4) on the extracted outcome data that present in at least 3 of the included studies. Mean difference (MD) was used as the effect size for continuous outcomes with a 95% confidence interval (CI) or standardized mean difference (SMD) in case of different outcome reporting scales. Results Pooled analysis showed that duloxetine significantly reduces pain intensity after 24 h from the operation compared to placebo (SMD = −1.11, 95% CI [−2.16 to −0.07], p = 0.04) with no significant difference in pain after 2 and 48 h. Meta‐analysis revealed that duloxetine shows a significant reduction in the amount of analgesic consumption after 24 h postoperative; (MD = −3.33, 95% CI [−5.53 to −1.13], p = 0.003). The analysis did not show any statistically significant difference between duloxetine and placebo in patients experiencing nausea or vomiting (RR = 1.37, 95% CI [0.62 to 3.00] Conclusion The findings of this study suggest that duloxetine may be effective in reducing pain 24 h after spine surgery. Furthermore, there is a promising effect of duloxetine in treating chronic postoperative pain. However, it is important to acknowledge that further research is warranted to thoroughly evaluate the efficacy and safety of duloxetine for relieving chronic postoperative pain.https://doi.org/10.1002/brb3.70217duloxetinepainspinesurgery |
| spellingShingle | Abdulsalam Mohammed Aleid Faisal Alshehri Naif Alasiri Fatimah Alhomoud Shouq Alsaegh Mohammed Alrasheed Salem Aljaddua Ali Alasiri Asma Boukhari Abdulmonem Ali Alhussain Bipin Chaurasia Saud Nayef Aldanyowi Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis Brain and Behavior duloxetine pain spine surgery |
| title | Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis |
| title_full | Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis |
| title_fullStr | Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis |
| title_full_unstemmed | Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis |
| title_short | Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis |
| title_sort | efficacy of duloxetine for postspine surgery pain a systematic review and meta analysis |
| topic | duloxetine pain spine surgery |
| url | https://doi.org/10.1002/brb3.70217 |
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