Targeting MYOF suppresses pancreatic ductal adenocarcinoma progression by inhibiting ILF3-LCN2 signaling through disrupting OTUB1-mediated deubiquitination of ILF3

Targeting MYOF suppresses pancreatic ductal adenocarcinoma progression by inhibiting ILF3-LCN2 signaling through disrupting OTUB1-mediated deubiquitination of ILF3

Pancreatic ductal adenocarcinoma (PDAC) is still a highly aggressive and fatal disease. The molecular mechanisms for PDAC progression are still not fully understood. Here, we demonstrated the overexpression of MYOF in PDAC in multiple sample sets, which is significantly associated with poor outcome...

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Bibliographic Details
Main Authors: Zhihui Li, Jianlei Zhang, Jiang Yin, Wen Ma, Hongfan Liao, Lv Ling, Qingfeng Zou, Yabing Cao, Ying Song, Guopei Zheng, Xiaoye Hu, Guohua Yang, Nan Li
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Redox Biology
Subjects:
Pancreatic cancer
MYOF
OTUB1
ILF3
LCN2
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001788
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