Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study

Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study

Abstract Background In observational studies, frailty has been strongly associated with mental disorders. However, the mechanisms underlying the association between frailty and mental disorders remain unclear. Methods We conducted a two-sample Mendelian randomization (MR) study to assess the causal...

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Bibliographic Details
Main Authors: Wenxi Sun, Ping Sun, Sijia Tang, Xiaohui Wu, Jun Chen, Yiru Fang, Xiaobin Zhang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Psychiatry
Subjects:
Mental disorders
Schizophrenia
Major depressive disorder
Frailty
Mendelian randomization
Causality
Online Access:https://doi.org/10.1186/s12888-024-06409-4
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https://doi.org/10.1186/s12888-024-06409-4

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