Global meta‐analysis reveals the drivers of gut microbiome variation across vertebrates
Abstract Shifts in gut microbial diversity and structure are one route by which vertebrate hosts adapt to local environmental conditions. However, recent studies have mostly been limited to a single species, small sample sizes, or restricted geographic ranges. Therefore, drawing a global picture of...
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| Format: | Article |
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Wiley
2024-12-01
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| Series: | iMetaOmics |
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| Online Access: | https://doi.org/10.1002/imo2.35 |
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| author | Yong Xie Songsong Xu Yufei Xi Zixin Li Erwei Zuo Kai Xing Lijing Bai Kui Li |
| author_facet | Yong Xie Songsong Xu Yufei Xi Zixin Li Erwei Zuo Kai Xing Lijing Bai Kui Li |
| author_sort | Yong Xie |
| collection | DOAJ |
| description | Abstract Shifts in gut microbial diversity and structure are one route by which vertebrate hosts adapt to local environmental conditions. However, recent studies have mostly been limited to a single species, small sample sizes, or restricted geographic ranges. Therefore, drawing a global picture of vertebrate gut microbiome diversity, community structure, and determinants for their adaptive shifts remains to be elucidated. We here collected 6508 samples from 113 vertebrate species covering diverse classes, feeding behaviors, and host habitats based on 16S rRNA gene sequencing. The results showed that host diet pattern had a significant impact on gut microbiome variation, which might drive taxonomic and functional contents of gut microbiome across vertebrates. Of note, the phylum Fusobacteria were enriched in carnivorous vertebrate gut while herbivorous vertebrate gut selectively increased the abundance of Verrucomicrobia. Also, climate factors were strongly associated with gut microbiome variation across vertebrates. Interestingly, we found that the abundance of microbiota belonging to Bacteroidetes increased gradually while the members from Proteobacteria showed a decreasing trend from high‐ to low‐latitude zones, potentially contributing to vertebrate adaptation to local climate condition. Additionally, we comprehensively deciphered the common antibiotic resistomes and their potential mobility between terrestrial vertebrate gut microbiome (n = 487) and their sympatric soil biological environment samples (n = 203) by integrating metagenomic sequencing datasets. Particularly, potential horizontal antibiotic resistance genes (e.g., bacA) transfers were detected between vertebrates gut microbiome and their sympatric soil biological environment. Together, our findings provide new evidence of how external environmental factors affect vertebrate gut microbiome variation. |
| format | Article |
| id | doaj-art-196f927871f9424e933d5d26c2ecf37c |
| institution | Kabale University |
| issn | 2996-9506 2996-9514 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
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| series | iMetaOmics |
| spelling | doaj-art-196f927871f9424e933d5d26c2ecf37c2025-01-31T16:15:24ZengWileyiMetaOmics2996-95062996-95142024-12-0112n/an/a10.1002/imo2.35Global meta‐analysis reveals the drivers of gut microbiome variation across vertebratesYong Xie0Songsong Xu1Yufei Xi2Zixin Li3Erwei Zuo4Kai Xing5Lijing Bai6Kui Li7Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen ChinaCollege of Animal Science and Technology China Agricultural University Beijing ChinaAnimal Science and Technology College Beijing University of Agriculture Beijing ChinaShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen ChinaShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen ChinaCollege of Animal Science and Technology China Agricultural University Beijing ChinaShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen ChinaShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen ChinaAbstract Shifts in gut microbial diversity and structure are one route by which vertebrate hosts adapt to local environmental conditions. However, recent studies have mostly been limited to a single species, small sample sizes, or restricted geographic ranges. Therefore, drawing a global picture of vertebrate gut microbiome diversity, community structure, and determinants for their adaptive shifts remains to be elucidated. We here collected 6508 samples from 113 vertebrate species covering diverse classes, feeding behaviors, and host habitats based on 16S rRNA gene sequencing. The results showed that host diet pattern had a significant impact on gut microbiome variation, which might drive taxonomic and functional contents of gut microbiome across vertebrates. Of note, the phylum Fusobacteria were enriched in carnivorous vertebrate gut while herbivorous vertebrate gut selectively increased the abundance of Verrucomicrobia. Also, climate factors were strongly associated with gut microbiome variation across vertebrates. Interestingly, we found that the abundance of microbiota belonging to Bacteroidetes increased gradually while the members from Proteobacteria showed a decreasing trend from high‐ to low‐latitude zones, potentially contributing to vertebrate adaptation to local climate condition. Additionally, we comprehensively deciphered the common antibiotic resistomes and their potential mobility between terrestrial vertebrate gut microbiome (n = 487) and their sympatric soil biological environment samples (n = 203) by integrating metagenomic sequencing datasets. Particularly, potential horizontal antibiotic resistance genes (e.g., bacA) transfers were detected between vertebrates gut microbiome and their sympatric soil biological environment. Together, our findings provide new evidence of how external environmental factors affect vertebrate gut microbiome variation.https://doi.org/10.1002/imo2.35antibiotic resistomesclimate variationdietgut microbiomemicrobial diversity |
| spellingShingle | Yong Xie Songsong Xu Yufei Xi Zixin Li Erwei Zuo Kai Xing Lijing Bai Kui Li Global meta‐analysis reveals the drivers of gut microbiome variation across vertebrates iMetaOmics antibiotic resistomes climate variation diet gut microbiome microbial diversity |
| title | Global meta‐analysis reveals the drivers of gut microbiome variation across vertebrates |
| title_full | Global meta‐analysis reveals the drivers of gut microbiome variation across vertebrates |
| title_fullStr | Global meta‐analysis reveals the drivers of gut microbiome variation across vertebrates |
| title_full_unstemmed | Global meta‐analysis reveals the drivers of gut microbiome variation across vertebrates |
| title_short | Global meta‐analysis reveals the drivers of gut microbiome variation across vertebrates |
| title_sort | global meta analysis reveals the drivers of gut microbiome variation across vertebrates |
| topic | antibiotic resistomes climate variation diet gut microbiome microbial diversity |
| url | https://doi.org/10.1002/imo2.35 |
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