Single-nucleus RNA sequencing uncovers metabolic dysregulation in the prefrontal cortex of major depressive disorder patients

Single-nucleus RNA sequencing uncovers metabolic dysregulation in the prefrontal cortex of major depressive disorder patients

Abstract Major depressive disorder (MDD) is a widespread psychiatric condition, recognized as the third leading cause of global disease burden in 2008. In the context of MDD, alterations in synaptic transmission within the prefrontal cortex (PFC) are associated with PFC hypoactivation, a key factor...

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Bibliographic Details
Main Authors: Xiang-Yao Li, Yingbo Rao, Guo-Hao Li, Luxi He, Yaohan Wang, Wenli He, Ping Fang, Chenyu Pei, Lun Xi, Haiyan Xie, Yun-Rong Lu
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
SnRNA-Seq
Major depressive disorder
Serum lactate
Glycolysis
KEGG
Online Access:https://doi.org/10.1038/s41598-025-92030-8
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https://doi.org/10.1038/s41598-025-92030-8

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