The accumulation of harmful genes within the ROH hotspot regions of the Tibetan sheep genome does not lead to genetic load

Abstract Background Prolonged natural selection and artificial breeding have contributed to increased uniformity within the Tibetan sheep population, resulting in a reduction in genetic diversity and the establishment of selective signatures in the genome. This process has led to a loss of heterozyg...

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Bibliographic Details
Main Authors: Lixia Sun, Chao Yuan, Tingting Guo, Yaqin Bai, Zengkui Lu, Jianbin Liu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Genomics
Subjects:
Online Access:https://doi.org/10.1186/s12864-025-11207-7
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