Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

Receptor interacting protein kinases (RIPK) RIPK1 and RIPK3 play important roles in diverse innate immune pathways. Despite this, some RIPK1/3-associated proteins are absent in specific vertebrate lineages, suggesting that some RIPK1/3 functions are conserved, while others are more evolutionarily la...

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Bibliographic Details
Main Authors: Elizabeth J Fay, Kolya Isterabadi, Charles M Rezanka, Jessica Le, Matthew D Daugherty
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
innate immunity
RIP kinases
NF-kB
vertebrate evolution
Online Access:https://elifesciences.org/articles/102301
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https://elifesciences.org/articles/102301

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