Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease

Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease

Abstract Impaired glucose uptake in the brain is an early presymptomatic manifestation of Alzheimer’s disease (AD), with symptom-free periods of varying duration that likely reflect individual differences in metabolic resilience. We propose a systemic “bioenergetic capacity”, the individual ability...

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Main Authors: Matthias Arnold, Mustafa Buyukozkan, P. Murali Doraiswamy, Kwangsik Nho, Tong Wu, Vilmundur Gudnason, Lenore J. Launer, Rui Wang-Sattler, Jerzy Adamski, The Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Metabolomics Consortium, Philip L. De Jager, Nilüfer Ertekin-Taner, David A. Bennett, Andrew J. Saykin, Annette Peters, Karsten Suhre, Rima Kaddurah-Daouk, Gabi Kastenmüller, Jan Krumsiek
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57032-0
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https://doi.org/10.1038/s41467-025-57032-0

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