Beclin‐1‐mediated activation of autophagy improves proximal and distal urea cycle disorders

Beclin‐1‐mediated activation of autophagy improves proximal and distal urea cycle disorders

Abstract Urea cycle disorders (UCD) are inherited defects in clearance of waste nitrogen with high morbidity and mortality. Novel and more effective therapies for UCD are needed. Studies in mice with constitutive activation of autophagy unravelled Beclin‐1 as druggable candidate for therapy of hyper...

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Main Authors: Leandro R Soria, Sonam Gurung, Giulia De Sabbata, Dany P Perocheau, Angela De Angelis, Gemma Bruno, Elena Polishchuk, Debora Paris, Paola Cuomo, Andrea Motta, Michael Orford, Youssef Khalil, Simon Eaton, Philippa B Mills, Simon N Waddington, Carmine Settembre, Andrés F Muro, Julien Baruteau, Nicola Brunetti‐Pierri
Format: Article
Language:English
Published: Springer Nature 2020-12-01
Series:EMBO Molecular Medicine
Subjects:
argininosuccinic aciduria
autophagy
OTC deficiency
Tat‐Beclin‐1 peptide
urea cycle disorders
Online Access:https://doi.org/10.15252/emmm.202013158
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https://doi.org/10.15252/emmm.202013158

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