Current concepts in the pathogenesis of spondyloarthritis
Pathogenesis of spondyloarthritis (SpA) is multifactorial and still not understood entirely. The role of genetics including human leukocyte antigen B27 has been investigated extensively, which along with genome-wide association studies has helped us understand and postulate various theories. Environ...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=5;spage=6;epage=12;aulast=Jain |
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| _version_ | 1832568756399767552 |
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| author | Nibha Jain Arumugam Moorthy |
| author_facet | Nibha Jain Arumugam Moorthy |
| author_sort | Nibha Jain |
| collection | DOAJ |
| description | Pathogenesis of spondyloarthritis (SpA) is multifactorial and still not understood entirely. The role of genetics including human leukocyte antigen B27 has been investigated extensively, which along with genome-wide association studies has helped us understand and postulate various theories. Environmental factors including gut dysbiosis, mechanical stress, and transduction have been implicated in the pathogenesis. Recently, the interleukin (IL)-17/IL-23 pathway has been major focus due to it being therapeutic target. Herein, we reviewed various recent developments and current concepts in the pathogenesis of SpA. |
| format | Article |
| id | doaj-art-18fefd1e9716405d9f015ceb3a7f0b76 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-18fefd1e9716405d9f015ceb3a7f0b762025-02-03T00:25:39ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012020-01-0115561210.4103/0973-3698.284745Current concepts in the pathogenesis of spondyloarthritisNibha JainArumugam MoorthyPathogenesis of spondyloarthritis (SpA) is multifactorial and still not understood entirely. The role of genetics including human leukocyte antigen B27 has been investigated extensively, which along with genome-wide association studies has helped us understand and postulate various theories. Environmental factors including gut dysbiosis, mechanical stress, and transduction have been implicated in the pathogenesis. Recently, the interleukin (IL)-17/IL-23 pathway has been major focus due to it being therapeutic target. Herein, we reviewed various recent developments and current concepts in the pathogenesis of SpA.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=5;spage=6;epage=12;aulast=Jaininterleukin 17interleukin 23pathogenesisspondyloarthritis |
| spellingShingle | Nibha Jain Arumugam Moorthy Current concepts in the pathogenesis of spondyloarthritis Indian Journal of Rheumatology interleukin 17 interleukin 23 pathogenesis spondyloarthritis |
| title | Current concepts in the pathogenesis of spondyloarthritis |
| title_full | Current concepts in the pathogenesis of spondyloarthritis |
| title_fullStr | Current concepts in the pathogenesis of spondyloarthritis |
| title_full_unstemmed | Current concepts in the pathogenesis of spondyloarthritis |
| title_short | Current concepts in the pathogenesis of spondyloarthritis |
| title_sort | current concepts in the pathogenesis of spondyloarthritis |
| topic | interleukin 17 interleukin 23 pathogenesis spondyloarthritis |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=5;spage=6;epage=12;aulast=Jain |
| work_keys_str_mv | AT nibhajain currentconceptsinthepathogenesisofspondyloarthritis AT arumugammoorthy currentconceptsinthepathogenesisofspondyloarthritis |