Assessment of candidate high-grade serous ovarian carcinoma predisposition genes through integrated germline and tumour sequencing

Assessment of candidate high-grade serous ovarian carcinoma predisposition genes through integrated germline and tumour sequencing

Abstract High-grade serous ovarian carcinoma (HGSOC) has a significant hereditary component, only half of which is explained. Previously, we performed germline exome sequencing on BRCA1 and BRCA2-negative HGSOC patients, revealing three proposed and 43 novel candidate genes enriched with rare loss-o...

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Main Authors: Deepak N. Subramanian, Maia Zethoven, Kathleen I. Pishas, Evanny R. Marinović, Simone McInerny, Simone M. Rowley, Prue E. Allan, Lisa Devereux, Dane Cheasley, Paul A. James, Ian G. Campbell
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-024-00447-3
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https://doi.org/10.1038/s41525-024-00447-3

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