Synthetic lethality in cancer: a protocol for scoping review of gene interactions from synthetic lethal screens and functional studies

Synthetic lethality in cancer: a protocol for scoping review of gene interactions from synthetic lethal screens and functional studies

Abstract Background Two genes are synthetically lethal if loss of function of either one of the two genes does not result in cell death, whereas loss of function of both genes together results in being detrimental to cell survival. This concept has been the basis for developing personalized, precisi...

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Main Authors: Raashi Chauhan, Rama Rao Damerla, Vijay Shree Dhyani
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Systematic Reviews
Subjects:
Synthetic lethal
DNA damage repair pathways
CRISPR/Cas9
Cancer
Targeted therapy
Online Access:https://doi.org/10.1186/s13643-025-02814-2
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https://doi.org/10.1186/s13643-025-02814-2

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