ARC/ARG3.1 binds the nuclear polyadenylate-binding protein RRM and regulates neuronal activity-dependent formation of nuclear speckles

ARC/ARG3.1 binds the nuclear polyadenylate-binding protein RRM and regulates neuronal activity-dependent formation of nuclear speckles

Summary: ARC is a neuronal activity-induced protein interaction hub with critical roles in synaptic plasticity and memory. ARC localizes to synapses and the nucleus, but its nuclear functions are little known. Following in vivo long-term potentiation (LTP) induction in the dentate gyrus, we show tha...

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Main Authors: Tambudzai Kanhema, Kamil Parobczak, Sudarshan Patil, Dagmara Holm-Kaczmarek, Erik I. Hallin, Jan Ludwiczak, Andrzej Antoni Szczepankiewicz, Francois Philippe Pauzin, Aamra Mahboob, Adrian Szum, Yuta Ishizuka, Stanisław Dunin-Horkawicz, Petri Kursula, Grzegorz Wilczynski, Adriana Magalska, Clive R. Bramham
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725002967
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