Progress and application of intelligent nanomedicine in urinary system tumors
Urinary system tumors include malignancies of the bladder, kidney, and prostate, and present considerable challenges in diagnosis and treatment. The conventional therapeutic approaches against urinary tumors are limited by the lack of targeted drug delivery and significant adverse effects, thereby n...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Journal of Pharmaceutical Analysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177924000613 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582146737307648 |
|---|---|
| author | Yingming Xiao Lei Zhong Jinpeng Liu Li Chen Yi Wu Ge Li |
| author_facet | Yingming Xiao Lei Zhong Jinpeng Liu Li Chen Yi Wu Ge Li |
| author_sort | Yingming Xiao |
| collection | DOAJ |
| description | Urinary system tumors include malignancies of the bladder, kidney, and prostate, and present considerable challenges in diagnosis and treatment. The conventional therapeutic approaches against urinary tumors are limited by the lack of targeted drug delivery and significant adverse effects, thereby necessitating novel solutions. Intelligent nanomedicine has emerged as a promising therapeutic alternative for cancer in recent years, and uses nanoscale materials to overcome the inherent biological barriers of tumors, and enhance diagnostic and therapeutic accuracy. In this review, we have explored the recent advances and applications of intelligent nanomedicine for the diagnosis, imaging, and treatment of urinary tumors. The principles of nanomedicine design pertaining to drug encapsulation, targeting and controlled release have been discussed, with emphasis on the strategies for overcoming renal clearance and tumor heterogeneity. Furthermore, the therapeutic applications of intelligent nanomedicine, its advantages over traditional chemotherapy, and the challenges currently facing clinical translation of nanomedicine, such as safety, regulation and scalability, have also been reviewed. Finally, we have assessed the potential of intelligent nanomedicine in the management of urinary system tumors, emphasizing emerging trends such as personalized nanomedicine and combination therapies. This comprehensive review underscores the substantial contributions of nanomedicine to the field of oncology and offers a promising outlook for more effective and precise treatment strategies for urinary system tumors. |
| format | Article |
| id | doaj-art-18a007cb5a5e4a268966d434fa574b9a |
| institution | Kabale University |
| issn | 2095-1779 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj-art-18a007cb5a5e4a268966d434fa574b9a2025-01-30T05:13:57ZengElsevierJournal of Pharmaceutical Analysis2095-17792024-12-011412100964Progress and application of intelligent nanomedicine in urinary system tumorsYingming Xiao0Lei Zhong1Jinpeng Liu2Li Chen3Yi Wu4Ge Li5Department of Urology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, ChinaDepartment of Urology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, ChinaDepartment of Urology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, ChinaDepartment of Urology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China; Corresponding author.Department of Urology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China; Corresponding author.Emergency Department, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China; Corresponding author.Urinary system tumors include malignancies of the bladder, kidney, and prostate, and present considerable challenges in diagnosis and treatment. The conventional therapeutic approaches against urinary tumors are limited by the lack of targeted drug delivery and significant adverse effects, thereby necessitating novel solutions. Intelligent nanomedicine has emerged as a promising therapeutic alternative for cancer in recent years, and uses nanoscale materials to overcome the inherent biological barriers of tumors, and enhance diagnostic and therapeutic accuracy. In this review, we have explored the recent advances and applications of intelligent nanomedicine for the diagnosis, imaging, and treatment of urinary tumors. The principles of nanomedicine design pertaining to drug encapsulation, targeting and controlled release have been discussed, with emphasis on the strategies for overcoming renal clearance and tumor heterogeneity. Furthermore, the therapeutic applications of intelligent nanomedicine, its advantages over traditional chemotherapy, and the challenges currently facing clinical translation of nanomedicine, such as safety, regulation and scalability, have also been reviewed. Finally, we have assessed the potential of intelligent nanomedicine in the management of urinary system tumors, emphasizing emerging trends such as personalized nanomedicine and combination therapies. This comprehensive review underscores the substantial contributions of nanomedicine to the field of oncology and offers a promising outlook for more effective and precise treatment strategies for urinary system tumors.http://www.sciencedirect.com/science/article/pii/S2095177924000613Intelligent nanomedicineUrinary system tumorsDrug deliveryBiological barriers |
| spellingShingle | Yingming Xiao Lei Zhong Jinpeng Liu Li Chen Yi Wu Ge Li Progress and application of intelligent nanomedicine in urinary system tumors Journal of Pharmaceutical Analysis Intelligent nanomedicine Urinary system tumors Drug delivery Biological barriers |
| title | Progress and application of intelligent nanomedicine in urinary system tumors |
| title_full | Progress and application of intelligent nanomedicine in urinary system tumors |
| title_fullStr | Progress and application of intelligent nanomedicine in urinary system tumors |
| title_full_unstemmed | Progress and application of intelligent nanomedicine in urinary system tumors |
| title_short | Progress and application of intelligent nanomedicine in urinary system tumors |
| title_sort | progress and application of intelligent nanomedicine in urinary system tumors |
| topic | Intelligent nanomedicine Urinary system tumors Drug delivery Biological barriers |
| url | http://www.sciencedirect.com/science/article/pii/S2095177924000613 |
| work_keys_str_mv | AT yingmingxiao progressandapplicationofintelligentnanomedicineinurinarysystemtumors AT leizhong progressandapplicationofintelligentnanomedicineinurinarysystemtumors AT jinpengliu progressandapplicationofintelligentnanomedicineinurinarysystemtumors AT lichen progressandapplicationofintelligentnanomedicineinurinarysystemtumors AT yiwu progressandapplicationofintelligentnanomedicineinurinarysystemtumors AT geli progressandapplicationofintelligentnanomedicineinurinarysystemtumors |