Dermal fibroblast-derived extracellular matrix (ECM) synergizes with keratinocytes in promoting re-epithelization and scarless healing of skin wounds: Towards optimized skin tissue engineering

Dermal fibroblast-derived extracellular matrix (ECM) synergizes with keratinocytes in promoting re-epithelization and scarless healing of skin wounds: Towards optimized skin tissue engineering

Skin serves as the first-order protective barrier against the environment and any significant disruptions in skin integrity must be promptly restored. Despite significant advances in therapeutic strategies, effective management of large chronic skin wounds remains a clinical challenge. Dermal fibrob...

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Bibliographic Details
Main Authors: Xiangyu Dong, Han Xiang, Jiajia Li, Ailing Hao, Hao Wang, Yannian Gou, Aohua Li, Saidur Rahaman, Yiheng Qiu, Jiahao Li, Ou Mei, Jiamin Zhong, Wulin You, Guowei Shen, Xingye Wu, Jingjing Li, Yi Shu, Lewis L. Shi, Yi Zhu, Russell R. Reid, Tong-Chuan He, Jiaming Fan
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-05-01
Series:Bioactive Materials
Subjects:
Dermal fibroblasts
Reversible immortalization
Extracellular matrix
Keratinocytes
Scarless wound healing
Skin tissue engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X2400567X
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