Development and biological characterization of the cyclic peptide cRGDTFI with potent binding affinity for integrins αvβ3 and αvβ5

Development and biological characterization of the cyclic peptide cRGDTFI with potent binding affinity for integrins αvβ3 and αvβ5

The arginine-glycine-aspartic acid (RGD) sequence is a motif that binds to integrins. RGD-containing peptides have applications in cancer treatment, tissue engineering, drug delivery, and imaging. The potent RGD-containing peptides cilengitide (cRGDfMeV) and iRGD (cCRGDKGDPC) show strong affinity fo...

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Bibliographic Details
Main Authors: Yuji Yamada, Seiya Ohki, Masumi Matsunuma, Masaki Mishima, Mitsuhiro Takeda, Teppei Ikeya, Tomomi Furihata, Keisuke Hamada, Yamato Kikkawa, Motoyoshi Nomizu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Materials & Design
Subjects:
Cyclic peptide
RGD motif
Integrin
Cell adhesion
Online Access:http://www.sciencedirect.com/science/article/pii/S026412752500886X
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http://www.sciencedirect.com/science/article/pii/S026412752500886X

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